About this episode

The episode discusses the relationship between mTOR, training frequency, and muscle growth, referencing historical training routines and modern recovery concepts.

In this episode of Hypertrophy Past & Present, Jake and Chris begin with a classic Clancy Ross full-body routine from the Silver Era, then move into a discussion about training frequency, mTOR, muscle protein synthesis, and whether training again before the previous hypertrophy stimulus has “finished” is actually a problem. Key topics include: • Clancy Ross’ 1940s full-body single set routine • Whether training a muscle every 48 hours can blunt hypertrophy • How repeated bout effect studies can be misapplied to training frequency • Why mTOR signalling is not the same thing as muscle growth • The role of oxidative stress and inflammation in post-workout recovery • How volume, frequency, stress, dieting, and athletic workloads affect recovery • Why the best training frequency is limited by recovery

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• 061 Does training hard help or hinder hypertrophy? · July 21, 2026 · 1h 30m
• 060 How to make your second set more stimulating · July 13, 2026 · 1h 17m
• 059 Hypertrophy is muscle-fibre specific · July 6, 2026 · 1h 48m
• 057 Full Body A/A/A vs A/B, which is right for you? · June 22, 2026 · 1h 38m
• 056 Most deloads are too short · June 15, 2026 · 1h 15m

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