#62: GLP-1s: Life-Changing Results… at What Cost?

#62: GLP-1s: Life-Changing Results… at What Cost?

February 5, 2026 · 51 min · Season 1 · Episode 62

About this episode

This episode explores the effects and trade-offs of GLP-1 drugs like semaglutide and tirzepatide on weight loss and overall health.

A medicine that quiets food noise, trims 15 to 20 percent of body weight, and even lowers the risk of heart events sounds like a fantasy—until you meet GLP-1 drugs. We dig into what makes semaglutide and tirzepatide so different, how they rewire satiety signals, and why their impact extends beyond the scale to blood sugar, blood pressure, and cardiovascular outcomes. Along the way, we get candid about the trade-offs: GI side effects, lean mass loss, and the reality that stopping often means r...

People in this episode

Host: Dr. Bobby Dubois

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Keywords

Mentioned in this episode

Products: GLP-1 drugs, semaglutide, tirzepatide

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