Microdosing GLP-1s: Weight Loss, Inflammation & Longevity

Microdosing GLP-1s: Weight Loss, Inflammation & Longevity

February 20, 2026 · 60 min · Episode 280

About this episode

Laura Conley discusses the use of GLP-1s and other peptides for weight loss, inflammation, and longevity in a replay of a webinar training.

Okay babes… this is a very special Free The Moms episode. This one is actually a replay-style webinar training that I hosted, and I decided to bring it to the podcast because this conversation needs to happen out loud. We are talking all things peptides. Yes, GLP-1s. And also NAD+, glutathione, B12, BPC-157 and more. But the main focus of this training is GLP-1s—why so many of my clients are taking them, why some are microdosing, why some are on a full weight-loss dose… and why I personally am on a microdose. I’ll be honest with you. I was nervous to release this. There is still so much stigma around GLP-1s. And I don’t love that. So we’re de-stigmatizing it. We’re having the conversation. Because my job is to bring you information, empowerment, and options—without shame. Inside this episode, I walk you through: - What peptides actually are (and why they’re not some scary foreign thing) - The difference between microdosing a GLP-1 and using a full weight-loss dose - Why I chose to microdose—and how I think about it in the context of longevity and metabolic health - Semaglutide vs tirzepatide (single agonist vs dual agonist) and what that actually means - What my clients are…

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