From the Archives: Inventor Mark Kokoris Debuts Roche’s New SBX Sequencer
About this episode
Mark Kokoris discusses the revolutionary SBX sequencing technology and its implications for genomics.
It was the biggest story in sequencing last year: Mark Kokoris, head of SBX sequencing at Roche and inventor of the technology, joins Mendelspod to talk about how Sequencing by Expansion (SBX) works and why it may redefine the limits of genomics. * 0:00 A long journey inspired by PCR * 7:20 What is sequencing by expansion? * 14:00 On scale and accuracy * 19:40 Multi-omics vision? * 24:40 What will be the killer app? * 30:00 Biggest challenge for launch Kokoris recounts the long path from co-founding Stratos Genomics in 2007 to Roche’s acquisition in 2020, when his team’s “wildly ambitious chemistry” finally found its match in Genia’s high-density nanopore platform. “Our approach to efficiently sequencing DNA,” he explains, “is to not sequence DNA. We rescale the problem—expand the molecule about 50-fold—so we can read it with much higher signal-to-noise.” The result is astonishing speed. Working with the Broad Institute and Boston Children’s Hospital, SBX delivered whole-genome results in under four hours, with the sequencing step itself taking only about 15 minutes. Kokoris attributes the achievement to a confluence of chemistry and compute. SBX’s duplex mode achieves…
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