533: Biohacking Gone Wrong: Why Everything You're Doing to Optimize Your Health Might Be Backfiring with Dr. Sabrina Solt

533: Biohacking Gone Wrong: Why Everything You're Doing to Optimize Your Health Might Be Backfiring with Dr. Sabrina Solt

June 23, 2026 · 1h 13m

About this episode

Natalie Jill discusses health optimization and the potential pitfalls of supplements with Dr. Sabrina Solt.

What if the supplements you've been taking to feel better are actually the reason you feel worse? That's exactly what happened to me, and it sent me down a rabbit hole that led to one of the most important conversations I've had about my own health. Today I'm sitting down with my close friend and personal doctor, Dr. Sabrina Solt, a regenerative medicine physician and peptide expert who has been in this field for over a decade. We start with the question that started everything for me: why was I wired at 3am, crashing every afternoon, and reacting to the exact supplements I thought were helping? Dr. Solt breaks down the cortisol-prolactin connection that most doctors never test for, explains why elevated cholesterol in midlife women is often a protective response rather than a red flag, and walks us through the inflammation markers that actually tell the full story of what's happening inside the body. Then we go deep on what she calls the upstream-downstream problem, the real reason why things like methylated B vitamins, NAD drips, and glutathione pushes can backfire so badly in certain women, and what to do instead. She explains the genetic piece around MTHFR and COMT…

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