Pregnenolone & Corticosteroids in Brain Health | Sherwood Brown | Episode 293

Pregnenolone & Corticosteroids in Brain Health | Sherwood Brown | Episode 293

May 15, 2026 · 1h 2m · Season 6 · Episode 293

About this episode

This episode discusses the role of pregnenolone and corticosteroids in brain health and their potential in treating mood and substance abuse disorders.

Send us Fan Mail Pregnenolone, a neurosteroid derived from cholesterol, affects brain activity and shows promise for treating mood and substance abuse disorders. TOPICS DISCUSSED: Steroid Biosynthesis: Cholesterol converted to pregnenolone, the precursor for all steroid hormones including cortisol, aldosterone, and sex hormones.Corticosteroids: Synthetic versions like prednisone primarily target glucocorticoid receptors for anti-inflammatory uses but can impact mood and cognition.Pregnenolone...

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