How Weight Loss Medications Actually Work in Your Body

How Weight Loss Medications Actually Work in Your Body

February 20, 2026 · 7 min

About this episode

This episode explains how GLP-1 receptor agonists work in the body to regulate appetite and metabolism.

Send us Fan Mail We break down the mechanism of action for GLP-1 receptor agonists like tirzepatide (Zepbound/Mounjaro) and semaglutide, explaining how these medications work in the body to regulate appetite and metabolism. • GLP-1 medications contain a C20 fatty diacid that binds to albumin, prolonging half-life • These drugs target both GIP and GLP-1 receptors to regulate appetite and caloric intake • Receptors are found in brain areas involved in appetite regulation and throughout the GI ...

People in this episode

Host: Dr. Damaris Grossmann

Topics covered

Keywords

Mentioned in this episode

Organizations: Zepbound, Mounjaro, GLP-1, GIP

Products: tirzepatide, semaglutide

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