194. Back to Basics - Metastatic Colorectal Cancer
From Oncology for the Inquisitive Mind by Michael Fernando and Josh Hurwitz
March 21, 2026 · 27 min · Season 4 · Episode 10
About this episode
This episode explores the intensification of chemotherapy and the use of monoclonal antibodies in treating metastatic colorectal cancer.
Metastatic colorectal cancer is one of the leading causes of cancer-related deaths and among the most common types of cancer worldwide. Chemotherapy remains the main treatment, but the question is: how can we make it more effective without increasing toxicity? This week, we explore the intensification of chemotherapy in an effort to improve overall survival. The second topic involves the use of monoclonal antibodies and targeted therapy to enhance existing regimens. Josh also conducts his characteristic deep dive, examining the evolution and application of the monoclonal antibodies cetuximab and panitumumab over the past 15 years. He aims to answer the long-standing question: does one size fit all for colorectal cancers? Studies discussed in this episode: FOLFOXIRI Beva/Cetux FIRE-3 Trial TAILOR Trial Crystal For more episodes, resources and blog posts, visit www.inquisitiveonc.com Please find us on Twitter @InquisitiveOnc! If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.com Art courtesy of Taryn Silver Music courtesy of AlisiaBeats: https://pixabay.com/users/alisiabeats-39461785/ Disclaimer: This podcast is for educational purposes…
People in this episode
Hosts: Michael Fernando, Josh Hurwitz
Topics covered
- metastatic colorectal cancer
- chemotherapy
- monoclonal antibodies
- targeted therapy
- overall survival
- cancer treatment
Keywords
- metastatic colorectal cancer
- chemotherapy
- monoclonal antibodies
- cetuximab
- panitumumab
- FOLFOXIRI
- FIRE-3 Trial
- TAILOR Trial
Sponsors
Pfizer, Gilead Pharmaceuticals, Merck Pharmaceuticals
Mentioned in this episode
Products: cetuximab, panitumumab
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- 201. Back to Basics - Advanced Gastric/GOJ Cancer · May 17, 2026 · 28 min
- 200. Back to Basics - Early Gastric Cancer · May 9, 2026 · 29 min
- 199. Back to Basics - Metastatic Colorectal Cancer - last line options · May 3, 2026 · 24 min
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