195. Back to Basics - Immunotherapy in Metastatic Colorectal Cancer
About this episode
This episode explores immunotherapy options for patients with microsatellite instability colorectal cancer.
Historically, colorectal cancer treatment has been fairly standard, but this has shifted over the past decade with the introduction of targeted therapies. This week, our focus is on patients with microsatellite instability (dMMR) colorectal cancer, a small but meaningful cohort. This condition affects up to 15% of patients, many of whom carry germline mutations in the MLH1 and MSH2 genes, which simply means that cells can't recognise and fix spontaneous mutations. Historically, these cancers are less responsive to chemotherapy. This week, we explore two immunotherapy regimens - pembrolizumab, ipilimumab and nivolumab. Studies discussed in this episode: Checkmate 8HW KEYNOTE-177 For more episodes, resources and blog posts, visit www.inquisitiveonc.com Please find us on Twitter @InquisitiveOnc! If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.com Art courtesy of Taryn Silver Music courtesy of AlisiaBeats: https://pixabay.com/users/alisiabeats-39461785/ Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice. Oncology for the Inquisitive Mind is recorded with the support of education grants from our…
Sponsors
Pfizer, Gilead Pharmaceuticals, Merck Pharmaceuticals
More episodes of Oncology for the Inquisitive Mind
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- 197. Back to Basics - Metastatic Colorectal Cancer - HER2 positive disease and PI3K mutations
- 196. Back to Basics - Metastatic Colorectal Cancer - BRAFV600E and KRAS
- 194. Back to Basics - Metastatic Colorectal Cancer
- 193. Genitourinary Cancers and Prof Jonathan E Rosenberg MD
- 192. Back to Basics - Early Colorectal Cancer - Part 2!
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