One of the Deadliest Cancers in America May Have Met Its Match

One of the Deadliest Cancers in America May Have Met Its Match

May 5, 2026 · 45 min

About this episode

The episode discusses recent breakthroughs in the detection and treatment of pancreatic cancer with Dr. Ajit Goenka.

Hard to detect and almost impossible to treat, pancreatic cancer has long been one of medicine’s most ruthless killers. For decades, it’s been the cancer that science couldn’t crack. But that might be starting to change. Recently, cancer researchers have announced a series of breakthroughs that, taken together, sound almost too good to be true: a drug that targets the “undruggable” gene behind most pancreatic tumors, a personalized mRNA vaccine that teaches the immune system to recognize pancreatic cancer as an enemy, and, now, an AI program that can spot the elusive disease years before doctors typically find it. So is this breakthrough a real turning point? Or another case of medical hype outrunning reality? On today’s episode, Dr. Ajit Goenka of the Mayo Clinic joins Derek to walk through the science behind the latest advances in cancer detection and what they could mean for the future of health care. They discuss Dr. Goenka’s new research using artificial intelligence to detect pancreatic cancer earlier than ever before … and whether machines might soon see what doctors can’t. Subscribe to our YouTube channel here: https://www.youtube.com/@PlainEnglishwithDerekThompson If you…

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Host: Derek Thompson

Guest: Dr. Ajit Goenka

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Organizations: Mayo Clinic, Spotify, The Ringer

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