Plain English with Derek Thompson

In 2017, Americans legally bet about $5 billion on sports. Last year, that number rose to $160 billion. Gambling hasn’t just taken over sports. It’s invaded culture, politics, and even international warfare. Bettors have already made millions of dollars wagering on the precise dates and locations of bombing campaigns in Iran, and journalists have been hounded for reporting on events that can lose bettors money. It’s one thing to believe, as I do, that it would be foolish to entirely ban sports gambling in the U.S. It’s another to watch the warp-speed casino-ification of American life and not think, “Something has gone badly wrong here!” McKay Coppins, a staff writer at The Atlantic, joins the show to discuss his new cover story on how gambling conquered sports … and everything else. Subscribe to our YouTube channel here: https://www.youtube.com/@PlainEnglishwithDerekThompson If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: McKay Coppins Producer: Devon Baroldi Links: https://www.theatlantic.com/magazine/2026/04/online-sports-betting-app-addiction/686061/ Source for all photos: Getty Images Learn more about your ad choices. Visit podcastchoices.com/adchoices

Why do placebo effects work, even when patients know that they're taking a sugar pill? How do "nocebo" effects work, and why do some people hold onto beliefs that they suspect might bring them pain and suffering? What do the major world religions have to teach secular athletes and workers about the power of belief, and what does the psychological research tell us about the benefits of prayer, even for those who don't believe in God? Nir Eyal, bestselling author of the new book Beyond Belief, joins the show to talk about the research behind how our beliefs shape our lives. Subscribe to our YouTube channel here: https://www.youtube.com/@PlainEnglishwithDerekThompson If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Nir Eyal Producer: Devon Baroldi Today’s open is adapted from Derek’s Substack essay “If Placebos Work So Well, Why Not Prescribe Sugar Pills For Everything?” Learn more about your ad choices. Visit podcastchoices.com/adchoices

What happens when the two biggest stories in the world—the Trump White House and the development of advanced artificial intelligence—collide? Well, nothing good, apparently. When contract negotiations broke down between the Pentagon and Anthropic, a leading AI lab, the Department of War took the extraordinary step of labeling Anthropic a "supply chain risk," a designation typically reserved for Chinese companies suspected of spying on American technology. It’s not just liberals like me that found this announcement jarring. The technology writer Dean Ball—who served as Senior Policy Advisor for AI at the White House as recently as last summer—said the decision amounted to a nearly tyrannical attack on private property. (After all, if the government can walk up to your company, make you a deal, and destroy your company if you say no, that certainly sounds like a world in which the state can destroy whatever it trains its eyes on.) So, I wanted to talk to Dean about what he sees—and why he thinks this episode is so important, and so terrifying. Today, we talk about the difference between Biden and Trump’s approach to artificial intelligence before diving into the Anthropic mess, and pulling out of it the bigger story, according to Dean: that Trump’s scattershot AI policy is just the latest sign that AI’s capabilities are growing faster than many people want to admit—this technology is going somewhere fast, and the the American government simply is not prepared for where it’s taking us. Subscribe to our YouTube channel here: https://www.youtube.com/@PlainEnglishwithDerekThompson If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Dean Ball Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

Dramatic regime change. Moderate regime evolution. A calamitous regional conflict. Or … no change at all. Today we consider how the Iran conflict might evolve following the killing of Supreme Leader Khamenei with Karim Sadjadpour, an American policy analyst at the Carnegie Endowment for International Peace. Subscribe to our YouTube channel here: https://www.youtube.com/@PlainEnglishwithDerekThompson If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek ThompsonGuest: Karim SadjadpourProducer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

The GLP-1 drug revolution has taken the medicine world by storm. I’ve done several episodes on the science of GLP-1s. But we’ve never done an episode like this before, where we talk to one of the most important people in charge of guiding the GLP-1 drug revolution. Our guest is Dave Ricks, the CEO of Eli Lilly, the largest pharmaceutical company in the world. First we talk about what makes the GLP-1 drug category special and the science that Lilly is doing to improve these drugs. Then, we talk about the pharmaceutical industry more broadly. How it works. How it could work better. And I don’t shy away from the question that I think Pharma CEOs need to take much more seriously: If the pharmaceutical industry is theoretically more devoted than any other economic category to saving people’s lives, why do Americans distrust it more than any other industry in the entire economy? Subscribe to our YouTube channel here: https://www.youtube.com/@PlainEnglishwithDerekThompson If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek ThompsonGuest: David RicksProducer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

In the mid-20th century, a group of media and communications scholars proposed that the shift from spoken to written language—from orality to literacy—transformed our politics, our media, our social relations, and even our sense of consciousness. Today we’re undergoing another shift: from a literate culture to something stranger—a post-literate world awash in social media and digital communications in which oral traditions are making a comeback. Bloomberg’s Joe Weisenthal, the cohost of the Odd Lots podcast, has called this one of the most important trends in the world. Today he explains how he got hooked on orality theory and why it’s the skeleton key that unlocks so many oddities of the modern world. Subscribe to our YouTube channel here: https://www.youtube.com/@PlainEnglishwithDerekThompson If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Joe Weisenthal Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

Hello! I’m back from paternity leave just in time to talk about the biggest media earthquake of the year (so far): the Washington Post meltdown. For decades, the Post was a journalistic gem with superior coverage of politics. Last week, billionaire owner Jeff Bezos decided to gut roughly a third of the staff after the paper lost hundreds of millions of dollars in the last few years. Today’s guest is Jim VandeHei, the cofounder of Politico and Axios and a former Post reporter. We talk about the decades-long rise and fall of the Post before zooming out to talk about the most important changes in news media over the past 20 years, the secret of 21st-century media success, and the coming storm of AI. To read more about Derek’s opening comments on how the future of the news industry is going back to past, check out his Atlantic article on the subject here: https://www.theatlantic.com/ideas/archive/2018/12/post-advertising-future-media/578917/ Subscribe to our YouTube channel here: https://www.youtube.com/@PlainEnglishwithDerekThompson If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Jim VandeHei Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices