154: Physiology-Guided Sepsis Resuscitation: ANDROMEDA-SHOCK 2, Dynamic Fluid Responsiveness, and SEP-1 with Guest Jaclyn Bond

About this episode

This episode discusses physiology-guided sepsis resuscitation and the implications of the ANDROMEDA-SHOCK 2 trial with guest Jaclyn Bond.

The science is finally catching up to what clinicians have long known: more fluids aren't always the answer to septic shock. In this episode, host Sarah Lorenzini and Jaclyn Bond MSN-LM, MBA-HM explain what the ANDROMEDA-SHOCK 2 trial reveals about physiology-guided sepsis resuscitation and why fixed-volume fluid strategies can lead to avoidable harm. They break down how dynamic fluid responsiveness testing helps teams stop guessing, and how tools like FloPatch support real-time assessment of carotid flow time and stroke volume. You'll leave with a clearer idea of when to give fluids, when to stop, and how to justify the decision. Topics discussed in this episode: The purpose and key findings of the ANDROMEDA-SHOCK 2 study Why dynamic measures of fluid responsiveness matter more than static vitals What recent meta-analysis data shows about physiology-guided fluid strategies Carotid flow time: what it is, how it’s measured, and how it guides decisions Hemodynamic assessment and bedside limitations How FloPatch supports real-time assessment so you can make individualized fluid decisions SEP-1 2026 guideline updates and why it’s better for patients How to apply these principles to…

People in this episode

Host: Sarah Lorenzini

Guest: Jaclyn Bond

Topics covered

• sepsis resuscitation
• fluid responsiveness
• ANDROMEDA-SHOCK 2 trial
• hemodynamic assessment
• SEP-1 guidelines
• clinical decision making

Keywords

• septic shock
• fluid strategies
• dynamic fluid responsiveness
• carotid flow time
• hemodynamic assessment
• SEP-1 updates

Mentioned in this episode

Organizations: ANDROMEDA-SHOCK 2, FloPatch, Rapid Response Academy, FloSonics Medical

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