Progesterone: Why Optimization and Replacement Matters During Your 30s, 40s and Beyond
About this episode
This episode discusses the critical role of progesterone in women's health, particularly during perimenopause, and its impact on sleep, anxiety, and mood stability.
Progesterone: Why Optimization and Replacement Matters During Your 30s, 40s and Beyond With Becca Pabona & Jeralee Kidd, Performance Medicine Nurses In this episode of The Rare Wellness Podcast , Performance Medicine Nurses Becca Pabona and Jeralee Kidd explore an often-overlooked but critically important hormone in women’s health: progesterone . While estrogen typically gets the spotlight in midlife conversations—especially around hot flashes and night sweats—this discussion highlights how progesterone is often the first hormone to decline during perimenopause , sometimes years before menopause begins. Becca and Jeralee break down: Why progesterone plays a key role in sleep quality, anxiety regulation, mood stability, and brain health How declining progesterone can lead to symptoms like insomnia (especially waking at 2–3 AM), “wired but tired” anxiety, mood swings, heavier periods, migraines, and worsening PMS The science behind progesterone’s calming effect on the brain through the GABA-A receptor pathway Why micronized (bioidentical) progesterone differs significantly from synthetic progestins used in earlier hormone studies The importance of symptom-guided optimization…
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