Rare Wellness Podcast (by Center for Regenerative and Performance Medicine)

Evidence Cited In This Episode1. Prostate Safety and the TRAVERSE Trial (Randomized Clinical Trial)Bhasin et al. Prostate Safety Events During Testosterone Replacement Therapy in Men With Hypogonadism: A Randomized Clinical Trial — JAMA Network Open (TRAVERSE).https://jamanetwork.com/journals/jamanetworkopen/fullarticle/28132932. Prostate Tissue Effects of TRTMarks et al., Effect of Testosterone Replacement Therapy on Prostate Tissue in Aging Men — JAMA 2006 (Demonstrates minimal change in prostate tissue androgen concentrations with TRT).https://www.hormonebalance.org/images/documents/Marks%2006%20Testosterone%20and%20Prostate%20cancer%20JAMA.pdf3. Prostate Risk and Monitoring During TRT (Review)Academic review of TRAVERSE and other randomized trials summarizing prostate safety outcomes and the importance of monitoring during TRT.https://academic.oup.com/jcem/article/109/8/1975/76754614. Harvard Health Commentary on TRT & Prostate Cancer RiskHarvard Health Publishing: Appropriate use of testosterone therapy does not appear to raise prostate cancer risk (comments on randomized evidence showing no increased risk over ~3 years).https://www.health.harvard.edu/mens-health/appropriate-use-of-testosterone-therapy-does-not-appear-to-raise-prostate-cancer-risk

Creatine is often labeled as a “gym supplement,” but it is so much more.In this episode of the Rare Wellness Podcast, Dr. Jamie Lewis breaks down what creatine really is, how it works inside the body, and why it’s one of the most researched and effective supplements for muscle strength, brain health, and healthy aging.In this episode, you’ll learn:• How creatine supports muscle strength and helps combat age-related muscle loss (sarcopenia)• Why creatine may improve cognitive performance and mental resilience under stress• The truth about creatine safety, kidney health, and common myths• Evidence-based dosing strategies for performance, longevity, and recovery• How creatine fits into regenerative and performance medicine programsCreatine isn’t a replacement for good sleep, nutrition, and training—but when those foundations are in place, it can be a powerful force multiplier for long-term health and function.🎙️ Hosted by Dr. Jamie Lewis🏥 Sponsored by Center for Regenerative and Performance Medicine🌐 Learn more at c4rpm.comIf you found value in this episode, please like, subscribe, comment, and share to help us continue delivering evidence-based wellness insights.

In this episode of the Rare Wellness Podcast, host Dr. Jamie Lewis breaks down the science behind exosomes, cutting through the hype to explain what they actually do — and what they don’t do — in regenerative medicine.Exosomes have rapidly gained attention in the wellness and orthopedic space, often advertised as injectable solutions for pain, injury, and anti-aging. But the real story is far more nuanced 🔬. Dr. Lewis explains that exosomes are biological messengers, not living cells — and that true healing requires activating your body’s own regenerative systems 🧬.🔑 Key Takeaways from This Episode:✅ What exosomes are and how they function as cellular “text messages”✅ Why platelets act as your body’s first responders 🚒✅ The critical role of stem cells as the “general contractors” of healing 🏗️✅ Why exogenous (donor-derived) exosomes don’t align with how biology actually works✅ The FDA’s position on off-the-shelf exosome products ⚠️✅ Why autologous regenerative therapies are biologically sound approachesDr. Lewis uses clear analogies and real-world examples to explain why real regeneration comes from living cells responding to your specific injury, not disconnected signals from a petri dish. This episode empowers you to make informed decisions and avoid misleading regenerative medicine claims.🌲 This episode is sponsored by the Center for Regenerative & Performance Medicine.Learn more at 👉 www. c4rpm.com👍 If you found this episode helpful, like, comment, and subscribe to the Rare Wellness Podcast for more bite-sized insights on longevity, hormone health, and regenerative medicine.

Creatine is not just for bodybuilders. In this episode of the Rare Wellness Podcast, Dr. Jamie Lewis sits down with Dr. Howard Grattan to break down the real science behind creatine and essential amino acids for muscle health, performance, and aging.Whether you're a serious athlete or just want to stay strong and healthy as you age, this episode is packed with takeaways you can apply right now.💪 What creatine actually does inside your body🍽️ Why essential amino acids (EAAs) are a game-changer for muscle growth🧬 How these supplements support longevity, recovery, and cellular function⚠️ Common myths about creatine and amino acids—debunked by the science✅ Dosage tips and timing strategies to maximize effectiveness🔬 Sponsored by the Center for Regenerative Medicine🌐 Learn more: c4rpm.com and rarewellness.comReferences for Show Notes: 1. Forbes SC, Little JP, Candow DG. Exercise and nutritional interventions for improving aging muscle health. J Cachexia Sarcopenia Muscle. 2021;12(1):1-21. doi:10.1002/jcsm.12659. [PMID: 33856389] 2. Devries MC, Phillips SM. Creatine supplementation during rehabilitation of disuse-induced muscle atrophy. J Physiol. 2020;598(12):2307-2319. [PMID: 32096063] 3. Turner CE, Byblow WD, Gant N. Creatine supplementation enhances cognitive performance and brain bioenergetics. J Int Soc Sports Nutr. 2020;17(1):1-10. [PMID: 32486065] 4. Dalle S, Rossmeislová L, Koppo K. The Role of Inflammation in Age-Related Sarcopenia. Front Physiol. 2019;10:302. doi:10.3389/fphys.2019.00302. [PMID: 30845725] 5. Jäger R, et al. International Society of Sports Nutrition Position Stand: Protein and exercise. J Int Soc Sports Nutr. 2017;14:20. [PMID: 28919842]

Can your metabolism make or break your regenerative treatment? In this episode of the Rare Wellness Podcast, Dr. Jamie Lewis breaks down the crucial link between metabolic health and regenerative outcomes.🧠 Discover why your body's ability to regulate blood sugar, inflammation, and cellular repair could determine whether treatments like PRP or stem cell therapy actually work.We cover:✅ How insulin resistance and inflammation sabotage recovery✅ Why muscle mass, sleep, and stress management matter more than you think✅ Practical strategies to improve your metabolic health before undergoing treatment✅ The future of regenerative medicine + performance optimizationIf you're investing in regenerative therapies, this episode is essential listening. Your internal environment could be the key to healing—or your biggest obstacle.🎧 Listen now and learn how to prep your body for optimal results.📚 References:[^1]: Wang M et al. Cell Metab. 2016;24(4):585-598.[^2]: Zhao Q et al. Stem Cells Int. 2020.[^3]: Di Martino A et al. Int Orthop. 2021;45(3):805–811.[^4]: Ko JH et al. Stem Cells Int. 2016.

Did you know that muscle is one of the most powerful predictors of long-term health and longevity? In this episode of the Rare Wellness Podcast, Dr. Jamie Lewis explores why building and maintaining muscle mass isn't just for athletes — it's critical for metabolic health, immune function, hormone balance, and even your brain.We break down the latest research on muscle as an endocrine organ, how it influences inflammation, insulin sensitivity, and the aging process, and what you can do starting today to preserve muscle and optimize your health. Whether you're dealing with chronic pain, recovering from injury, or simply want to age well, this episode is a must-listen.🎙 Hosted by Dr. Jamie Lewis💥 Sponsored by Northwest Center for Regenerative Medicine👉 Like, comment, and subscribe for more science-backed strategies to take control of your health.

Choosing a regenerative medicine clinic isn't just about location — it's about quality, expertise, and making sure you're getting the right menu of treatments for your specific needs. In this episode of the Rare Wellness Podcast, Dr. Jamie Lewis breaks down why "the menu matters" when selecting a clinic for stem cell therapy, PRP, and other regenerative treatments.Learn how to spot the difference between clinics that offer one-size-fits-all solutions and those that customize your care based on your biology. We’ll explore key factors you should look for: like treatment options, platelet dose measurement, stem cell sourcing, and how clinics track outcomes.Your health deserves more than guesswork. Whether you're seeking healing for knee osteoarthritis, tendon injuries, or other chronic conditions, knowing what questions to ask can make all the difference.🎙 Hosted by Dr. Jamie Lewis🎯 Sponsored by Northwest Center for Regenerative Medicine📍 Learn more: nwc4rm.com and rarewellness.com💡 Don’t forget to like, comment, and subscribe for more expert wellness insights!

Is knee pain slowing you down? Before you commit to surgery, discover a powerful, non-invasive alternative: stem cell therapy.In this episode of the Rare Wellness Podcast, Dr. Jamie Lewis breaks down how regenerative stem cell treatments are helping patients with knee osteoarthritis regain mobility, reduce pain, and avoid knee replacements altogether. Learn how these cutting-edge therapies use your body’s own cells to restore damaged tissue, reduce inflammation, and promote long-term healing.Whether you’re an athlete, an active adult, or someone simply looking to stay mobile as you age, this episode is packed with insights on how stem cell therapy can help you stay on your feet—without going under the knife.✅ Learn how stem cell therapy works✅ Who’s a good candidate for regenerative knee treatments✅ How it compares to surgery and cortisone shots✅ What kind of results to expect🎙 Hosted by Dr. Jamie Lewis💉 Sponsored by the Northwest Center for Regenerative Medicine → nwc4rm.com and www.rarewellness.com👇 Like, comment, and subscribe for more natural solutions to chronic pain, aging, and performance optimization.