Caffeine, Tolerance, and Getting Your Pre-Workout to Work Again with Dr. Eric Trexler
From RP Strength Podcast by Nick Shaw
March 30, 2026 · 54 min
About this episode
The episode discusses the effects of caffeine on fitness, including tolerance, effective dosing, and practical applications for gym-goers.
Want to get even more jacked? Grab the RP Hypertrophy App for your training, and maximize your gym efforts with the RP Diet Coach App to nail your nutrition. Dr. Eric Trexler's Links: RP article: Caffeine, The Double-Edged Sword Stronger by Science: The Lifter's Guide to Caffeine Instagram: @trexlerfitness ResearchGate: Eric Trexler publications Twitter/X: @EricTrexler Timestamps: 00:00 Eric and Nick's BEEF 🥩 06:53 Caffeine's prevalence in fitness 09:10 Eric's caffeine research background 11:04 Daily caffeine intake (1g/day of caffiene safe?) 17:30 Effective dosing by bodyweight and when high doses backfire 22:30 Tolerance and habituation: why your caffeine stops working 30:15 Caffeine withdrawal: symptoms, timeline, and how bad it actually gets 41:30 Caffeine sensitivity and genetics 44:00 Practical upper limits and sleep tradeoffs 48:00 Strategic caffeine use, deloads, and re-sensitizing 50:15 Different delivery forms: drinks, food, pills, and gum 53:45 Does caffeine Dehydrate you? Wrap-up and where to read more
People in this episode
Host: Nick Shaw
Guest: Dr. Eric Trexler
Topics covered
- caffeine
- fitness
- nutrition
- tolerance
- pre-workout
- caffeine sensitivity
Keywords
- caffeine
- tolerance
- pre-workout
- fitness
- nutrition
- caffeine sensitivity
- caffeine withdrawal
- effective dosing
Mentioned in this episode
Organizations: RP Hypertrophy App, RP Diet Coach App, Stronger by Science, ResearchGate, Instagram, Twitter/X
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