RP Strength Podcast

Nick Shaw and Dr. Eric Trexler discuss oral GLP-1 options, how the newer drugs compare, and practical questions about dosing, side effects, muscle retention, and possible benefits beyond weight loss. They also examine research on weight regain after stopping treatment, the cost of long-term access, and how these medications may affect food cravings and behavior. Want to get even more jacked? Grab the RP Hypertrophy App for your training, and maximize your gym efforts with the RP Diet Coach App to nail your nutrition. Dr. Eric Trexler's Links: Instagram: https://www.instagram.com/trexlerfitness/ ResearchGate: https://www.researchgate.net/profile/Eric-Trexler MASS Research Review: https://massresearchreview.com/ 00:00:00 Intro and football banter 00:03:21 Why GLP-1s are everywhere 00:08:17 Dosing and tolerability 00:11:12 Oral GLP-1 options 00:17:55 Single, dual, and triple agonists 00:21:59 How much weight loss do trials show? 00:26:53 Side effects and protecting muscle 00:31:34 Health effects beyond weight loss 00:34:53 Reward, cravings, and enjoyment 00:46:05 Weight regain after stopping 00:50:42 Cost and long-term access 00:53:57 What wider access could change

Want to get even more jacked? Grab the RP Hypertrophy App for your training, and maximize your gym efforts with the RP Diet Coach App to nail your nutrition. Dr. Milo Wolf's Links: YouTube: @DrMiloWolf Instagram: @drmilowolf ResearchGate: Milo Wolf 00:00 Intro, gardening, and the UK heat 07:01 Is one gram per pound enough? 08:02 Where the 1.6 g/kg recommendation came from 15:34 Newer protein research and diminishing returns 19:51 Higher protein during a cut 22:00 Trading carbs for protein: performance versus muscle growth 29:10 Pre-workout carbs and training hungry 40:11 Research updates and Milo's protein targets 46:15 Practical ways to eat more protein 52:26 Protein shakes, fullness, and filling meal ideas 56:26 Final protein takeaways

Want to get even more jacked? Grab the RP Hypertrophy App for your training, and maximize your gym efforts with the RP Diet Coach App to nail your nutrition. Dr. Pak's Links: Website: drpak.com Instagram: @dr__pak YouTube: @Dr__Pak Book: Train Smarter, Not Longer 00:00 Why deloads are so controversial 01:40 What deloads were originally supposed to do 03:03 The first research and the case for reactive deloads 05:27 What studies on time off actually show 07:20 How Nick and Mike discovered deloads in practice 15:47 Training around aches, fatigue, and heavy workloads 20:10 Verify fatigue with performance before taking time off 26:17 Beginners, advanced lifters, and deload frequency 28:01 Vacations and real-life opportunities to reduce training 36:05 Exercise swaps, pain management, and staying consistent 40:22 Nick's practical approach to scheduled deloads 48:14 Coaching athletes through an intentionally easier week

Want to get even more jacked? Grab the RP Hypertrophy App for your training, and maximize your gym efforts with the RP Diet Coach App to nail your nutrition. Guest Links Dr. Milo Wolf's Links: YouTube: @DrMiloWolf Instagram: @drmilowolf ResearchGate: Milo Wolf Timestamps 00:00 Gardening, healthy eating, and body composition 04:09 Is body recomposition fact or fiction? 08:11 What recomp studies show from beginners to advanced lifters 14:05 Maintenance versus a calorie surplus 18:49 How much energy muscle growth actually requires 23:28 Who should choose recomp instead of bulking 30:09 Body-fat level, leanness, and when recomp is a poor fit 36:13 Advanced lifters and the difficulty of measuring progress 40:14 Training and recovery at maintenance 44:01 Recomp after injury or a major change in training status 47:00 Patience, coaching, and recognizing slow progress 51:20 Protein, calories, and practical recomp guidelines

Want to get even more jacked? Grab the RP Hypertrophy App for your training, and maximize your gym efforts with the RP Diet Coach App to nail your nutrition. Guest Links Dr. Milo Wolf's Links: YouTube: @DrMiloWolf Instagram: @drmilowolf ResearchGate: Milo Wolf Timestamps 00:00 Heat, sweating, and World Cup banter 07:40 What rep ranges actually build muscle? 12:30 The effective 4-to-50-rep range and muscle fiber types 15:50 Can you tell whether you are fast-twitch or slow-twitch? 21:56 Fiber types in sports, bodybuilding, and powerlifting 26:01 Why 4 to 12 reps has a practical advantage 29:07 Volume, proximity to failure, and stretch matter more 35:02 Matching rep ranges to pain, experience, and exercise selection 39:02 How to train for strength and muscle growth together 44:42 High reps versus heavy sets: physical and psychological fatigue 49:47 What the fatigue research shows and the final recommendations

Want to get even more jacked? Grab the RP Hypertrophy App for your training, and maximize your gym efforts with the RP Diet Coach App to nail your nutrition. Guest Links Dr. Eric Trexler's Links: Instagram: @trexlerfitness ResearchGate: Eric Trexler publications Research review: MASS Research Review Timestamps 00:00 Conference travel, weight-loss non-responders, and the episode setup 07:03 What counts as a training non-responder? 08:53 Measurement error and why short studies can mislead 10:53 Replication and better individualized research designs 16:30 General response versus program-specific response 19:25 Why advanced lifters struggle to measure small changes 33:34 Can muscle fiber type affect training responsiveness? 37:22 Why narrower studies produce better answers 39:28 Are true non-responders real? 44:10 What to do when your progress is unusually slow 50:27 Before you give up: time, volume, intensity, and mindset 54:39 The calf-training example, Eric's links, and closing

Want to get even more jacked? Grab the RP Hypertrophy App for your training, and maximize your gym efforts with the RP Diet Coach App to nail your nutrition. Dr. Pak's Links: Instagram: @dr__pak YouTube: @Dr__Pak Website: drpak.com Timestamps: 00:00 Intro and Dr. Pak's secret Greek rap career 05:00 Big rock 1: sleep regularity matters more than total duration 12:40 Why dieting and being lean wrecks your sleep 15:05 Big rock 2: stress management and mindfulness 18:35 Big rock 3: managing training load 22:30 Cold water immersion: good for soreness, bad for post-workout hypertrophy signaling 25:40 Sauna: neutral to positive for muscle growth and a better bet than cold 34:00 When cold actually makes sense: in-season athletes on back-to-backs 36:00 Massage: soreness and flexibility benefits but no magic for muscle growth 40:30 Massage guns: mixed evidence, impairs explosive performance if used pre-workout 45:00 Cannabis and alcohol: occasional is fine, daily use is a net negative 58:00 Don't skip the big rocks chasing the gimmicks