
310. The Fatigue Resistance Episode! Rachel Entrekin Makes History at Cocodona, Women v. Men Durability, Fueling and the Central Nervous System, Brain Changes, and More
From Some Work, All Play by David Roche and Megan Roche
May 12, 2026 · 1h 34m
About this episode
The episode discusses fatigue resistance in endurance sports, featuring Rachel Entrekin's win at Cocodona 250 and exploring gender differences in durability and fueling strategies.
We had some HYPOTHESES for this amazing episode! The main topics all revolved around fatigue resistance (often called “durability” in the literature), which we think is the most exciting area of training theory and physiology. It started with Rachel Entrekin’s legendary overall win at the Cocodona 250, an event that explores some of the strangest and coolest parts of endurance. Our big theory: what we’re seeing in these wild ultras is directly connected to what we see in short distances. A new study looked at fatigue resistance variations between men and women, with some shocking results. We expand the scope to talk about the literature generally before going to some ideas for how it all might relate to the central nervous system. ...And how it relates to fueling. You could probably guess that we were going to talk about carbs. Plus, we answer questions about the culture of fueling for young athletes and feeling good after long runs! This one starts with a description of Megan’s health journey. The hottest vacation is apparently a 3-day stay in Boulder Community Hospital. Things are scary, but we’re holding onto hope for the future. We love you all! HUZZAH! -David and Megan Click…
People in this episode
Hosts: David Roche, Megan Roche
Guest: Rachel Entrekin
Topics covered
- fatigue resistance
- endurance
- durability
- fueling
- central nervous system
- gender differences in endurance
- athlete health
Keywords
- fatigue resistance
- endurance
- Cocodona 250
- fueling
- central nervous system
- gender differences
- athlete health
- carbohydrates
- ultramarathons
- training theory
Sponsors
The Feed, Janji, Wahoo Fitness
Mentioned in this episode
Organizations: Boulder Community Hospital
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