244: The Metabolic Root of Depression, Anxiety, & Mental Illness - Dr. Lori Calabrese

244: The Metabolic Root of Depression, Anxiety, & Mental Illness - Dr. Lori Calabrese

April 7, 2026 · 52 min · Episode 244

About this episode

Dr. Lori Calabrese discusses how metabolic interventions, particularly ketogenic diets, can lead to remission in mental health conditions.

Dr. Lori Calabrese is a psychiatrist whose trajectory changed when a patient with 15 years of treatment-resistant anorexia went into full remission after a ketogenic diet. What followed was a research journey — pilot studies, peer-reviewed case series, and a now-funded randomized controlled trial — consistently showing that depression, anxiety, OCD, bipolar disorder, and other conditions could achieve complete remission, not just symptom reduction, through metabolic intervention. The key mech...

People in this episode

Host: Dr. Philip Ovadia

Guest: Dr. Lori Calabrese

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Mentioned in this episode

Organizations: ketogenic diet

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