EP 85: COMT Gene Explained: Are You a Warrior or a Worrier?

EP 85: COMT Gene Explained: Are You a Warrior or a Worrier?

February 23, 2026 · 32 min

About this episode

This episode explores the COMT gene and its impact on personality, stress tolerance, and health.

In this episode, we break down one of the most talked-about (and misunderstood) topics in functional medicine: methylation and the COMT gene . What does it really mean to have a methylation gene variant? How common is it? And what’s the difference between being a “warrior” vs a “worrier”? We dive into: 🧬 What methylation is and why it matters for brain chemistry, hormones, detoxification, and cardiovascular health 📊 The likelihood of Americans carrying some form of methylation-related gene variant 🧠 What the COMT gene does when it’s functioning properly (dopamine, estrogen, stress response) ⚖️ The three COMT variants — Val/Val, Val/Met, Met/Met — and how they influence personality, stress tolerance, and focus 🔥 “Warrior vs Worrier” explained ⚠️ Symptoms associated with slower or faster COMT activity 🧪 How to test (genetic testing, bloodwork, organic acid testing) 💊 What you can actually do about it — lifestyle, stress management, targeted supplementation, and methylation support If you’ve struggled with anxiety, brain fog, hormone imbalances, poor stress tolerance, or feeling “wired but tired,” this episode will help you understand how your genetics may be influencing your…

People in this episode

Hosts: Dr. Roy Korth, Daniela Korth

Topics covered

Keywords

Mentioned in this episode

Organizations: COMT gene, functional medicine, Americans, dopamine, estrogen, stress response, methylation, bloodwork, organic acid testing

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