Episode 153: COMT - Why Some Nervous Systems Feel Everything More Intensely

Episode 153: COMT - Why Some Nervous Systems Feel Everything More Intensely

June 25, 2026 · 13 min

About this episode

In this episode, Anna explores the role of COMT in nervous system sensitivity and its implications for stress processing.

Some people notice that they seem to experience stimulation and stress more intensely than others. They may feel overwhelmed in busy environments, react strongly to caffeine, or find it difficult to switch off mentally after a demanding day. Sometimes people encounter the term COMT when exploring genetic testing and begin to wonder whether this might explain their nervous system sensitivity. But conversations about COMT online can quickly become confusing — and sometimes unnecessarily alarming. In this episode, Anna explores what COMT actually does in the body, how it influences the way we process certain stress-related brain chemicals, and why some nervous systems naturally experience stimulation more strongly than others. Most importantly, we discuss why COMT is not a defect, but rather a pattern of biological sensitivity that can have both challenges and strengths. Useful Links Take the Chronic Fatigue Quiz: https://app.annamarsh.co.uk/quiz-page Instagram: https://www.instagram.com/anna__marsh_ Work with me: https://annamarsh.co.uk/work-together/ Website: http://annamarsh.co.uk/ Join the Nurturing Resilience Subscription: https://annamarsh.co.uk/nurturing-resilience/

People in this episode

Host: Anna Marsh

Mentioned in this episode

Organizations: Chronic Fatigue Quiz, Instagram, Nurturing Resilience Subscription, annamarsh.co.uk

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