Antidepressants Explained: Benefits, Risks, and Alternatives for Depression | Dr. James Greenblatt

Antidepressants Explained: Benefits, Risks, and Alternatives for Depression | Dr. James Greenblatt

From The Dr. Hyman Show by Dr. Mark Hyman

June 3, 2026 · 55 min

About this episode

Dr. Mark Hyman and Dr. James Greenblatt discuss the complexities of depression and the importance of understanding its underlying causes.

Depression is often treated as a single condition. But two people with the same diagnosis can have completely different underlying causes. On this episode of The Dr. Hyman Show, I’m rejoined by Dr. James Greenblatt to explore why depression may be less of a disease and more of a signal that something deeper is going on. We discuss how a root-cause approach can uncover what’s driving symptoms and why finding what’s beneath them matters. Watch the full conversation on YouTube or listen wherever you get your podcasts. We discuss: Could nutrient deficiencies, inflammation, or gut issues be contributing to symptoms of depression What tests can help uncover the biological factors that may be affecting mood and mental health Why can two people with depression have different root causes—and require different solutions How do blood sugar imbalances, hormone changes, and metabolic health influence the brain What should you know about antidepressants, tapering, and addressing the factors that may affect recovery Hope doesn't come from ignoring symptoms—it comes from understanding them. Sometimes the most important question isn't "What's wrong with me?" but "What might my body be trying to…

People in this episode

Host: Dr. Mark Hyman

Guest: Dr. James Greenblatt

Topics covered

  • depression
  • root-cause approach
  • mental health
  • nutrient deficiencies
  • biological factors
  • antidepressants

Keywords

  • depression
  • mental health
  • antidepressants
  • nutrient deficiencies
  • biological factors
  • root causes
  • gut issues

Mentioned in this episode

Organizations: Brainshaping Academy

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