The Dr. Hyman Show

How well is your brain aging? Your birthday tells you one thing, but your brain may tell a different story. Today, I’m talking with neuroscientist Paul Thompson, PhD, whose work with the global ENIGMA Consortium is revealing how brain health connects to what’s happening throughout your body. We get into what brain scans can tell us and why those findings matter to you. We discuss: What your “brain age” means and how it can differ from your actual age Why your metabolic health deserves attention when you’re struggling with mood or memory How sleep and nutrition support your brain’s ability to function and recover What having an Alzheimer’s risk gene does, and doesn’t, tell you about your future How brain scans, blood tests, and AI could help identify the right treatment for you It’s so exciting to see researchers like Paul looking across thousands of brain scans and uncovering connections between the health of the body and the brain. For me, it opens up a bigger conversation about how we care for ourselves and how our everyday habits can help protect our memory and support our mood as we age. View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journalhttps://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Healthhttps://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive This episode is brought to you by BON CHARGE, Paleovalley, Timeline, Seed, BIOptimizers, and Fatty15. Explore red light products at boncharge.com/hyman and enjoy 15% off with code HYMAN. Shop nutrient-rich foods and supplements at paleovalley.com/hyman and save 15% off your first order. Support healthy aging and get up to 20% off when you subscribe on top of the new starting price of $79 at timeline.com/drhyman. Make your microbiome part of your daily routine with seed.com/hyman and save 25% with code 25HYMAN. Use bioptimizers.com/hyman and code HYMAN for 15% off, special bonuses, and a 365-day money-back guarantee. Head to fatty15.com/HYMAN today and use code HYMAN for 15% off your 90-day subscription Starter Kit. 0:00 Paleo Valley Superfood Bars 2:50 Enigma and Brain Mapping 10:30 Psychiatry Meets Brain Biology 18:35 The Brain-Body Connection 24:30 Mapping Mental Health Patterns 31:30 Brain Age and Biomarkers 36:59 Sleep, Nutrition, and Recovery 47:38 A Case of Brain Repair 52:50 Genes, Risk, and Protection 59:15 Brain Charts and Diagnostics 1:12:26 AI for Alzheimer’s Disease 1:20:06 Imaging and Prevention

What if the fatigue, brain fog, bloating, and cravings you've accepted as normal are actually signs that something you're eating isn't working for your body? You may not realize how much your food is affecting you until you change it. In this episode, I break down why I created the 10-Day Detox, what happens inside your body when you remove common dietary triggers, and how just 10 days can reveal important clues about your health. Here's what we discuss in today's episode: Why you might feel tired, bloated, or foggy even when you think you're eating healthy The surprising changes that can happen inside your body in just 10 days Why the first few days of a dietary reset can be the hardest—and what happens next The common foods that may be quietly contributing to inflammation, cravings, and metabolic dysfunction What to eat during the 10-Day Detox and how to reintroduce foods afterward to identify your personal triggers The goal isn't another restrictive diet or a quick fix for weight loss. It's to understand how food affects your body. When you start connecting what you eat with how you feel, you gain the information you need to make better decisions for your long-term health. Resources Mentioned: Explore my 10-Day Detox, including recipes and meal plan, group coaching, and a supportive community: https://10daydetox.com Start your detox anytime! Complete Program members can also join our next group detox in January 2027. The Blood Sugar Solution 10-Day Detox Diet by Dr. Mark Hyman Have a question you'd love answered on Office Hours? Submit it here. Help Us Win a Listener’s Choice Award The Dr. Hyman Show is a finalist in the Signal Awards, and the Listener’s Choice Award is decided by you. If the show has helped you ask better questions or take better care of your health, I’d be grateful for your vote. Just sign up for an account to vote before October 15. Thank you for making these conversations part of your life. Vote Here

Early in my career, I noticed that patients’ skin often improved as we addressed their nutrition and gut health. That changed how I approached skin concerns and taught me to look beneath the surface for contributing factors. Today, I’m joined by triple board-certified dermatologist Dr. Mamina Turegano, co-author of The Holistic Psoriasis Management and Nutrition Guide and an advocate for Timeline’s approach to skin health. Together, we explore what your skin can reveal about your overall health and how that understanding can help you make more informed choices about caring for it. You’ll learn: How damaged mitochondria contribute to skin aging, and how urolithin A may support healthier skin through mitochondrial renewal How your gut health, hormones, and insulin resistance may be contributing to recurring acne and other skin concerns How menopause changes your skin, and what to consider if it becomes drier, thinner, or less resilient How strength training may benefit your skin alongside your muscles Which skincare basics to prioritize before investing in newer treatments and supplements Like most people, I care about how my skin looks, but I also want to understand what helps it stay healthy and resilient. That’s how I approach aging more broadly: learning what my body needs and making those choices part of everyday life. Help Us Win a Listener’s Choice Award The Dr. Hyman Show is a finalist in the Signal Awards, and the Listener’s Choice Award is decided by you. If the show has helped you ask better questions or take better care of your health, I’d be grateful for your vote. Just sign up for an account to vote before October 15. Thank you for making these conversations part of your life. View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journalhttps://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Healthhttps://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive This episode is brought to you by Timeline, Sunlighten, Perfect Amino, Seed, BIOptimizers, and Pique. Don’t miss Timeline’s lowest prices of the year. Save 30% on a one-time purchase or 35% when you subscribe and save, plus free shipping. Offer ends October 11. Discover why so many people are using sunlighten.com. Use code HYMAN to save up to $2,100 today and free shipping. Help fill protein gaps at bodyhealth.com and use code HYMAN20 for 20% off. Make your microbiome part of your daily routine with seed.com/hyman and save 25% with code 25HYMAN. Use bioptimizers.com/hyman and code HYMAN for 15% off, special bonuses, and a 365-day money-back guarantee. Elevate your daily wellness ritual at piquelife.com/hyman and enjoy 20% off plus free gifts. 0:00 Strength training, skin thickness, and Sponsor: Timeline 1:46 Sunlighten infrared sauna, SIGNAL awards, and integrative dermatology from the inside out 5:53 Transition from conventional to holistic dermatology 9:29 Beyond the skin: diet, sleep, stress, hormones, and environment 10:14 Gut health, insulin resistance, and chronic skin disease drivers 12:23 Testing for SIBO, H. pylori, hormones, and gluten sensitivity 14:23 Sugar, dairy, environmental toxins, stress, caffeine, and inflammation as acne triggers 18:54 Functional treatment case: acne and psoriasis improvement 20:24 Comprehensive psoriasis workup and hidden drivers 22:16 Challenges in nutrition and lifestyle research; clinical observation 23:08 Healthy skin diet: Mediterranean eating, protein, fats, fiber, polyphenols, and processed foods 24:26 Elimination diets and foundational nutrients for skin health 27:50 The impact of hormones on skin health and aging 31:57 Functional medicine case studies: psoriasis, arthritis, and gut-focused treatment 36:25 Skin aging: effects of nutrition, lifestyle, hormones, and topical care 39:52 Alcohol, oxidative stress, and collagen breakdown in aging 41:00 Collagen supplements and UV radiation impact on skin 46:00 Supporting skin mitochondria: mitophagy, sleep, stress, exercise, and supplements 49:52 Urolithin A, polyphenols, carotenoids, and Sponsor: Timeline, Biooptimizers, Peak 54:52 Reversing skin aging and the role of strength training 57:42 Sun protection strategies for skin longevity 59:11 Melanoma risk, sun exposure patterns, and vitamin D 1:00:26 Major drivers of skin aging: sun, smoking, sugar, sleep, stress, exercise, pollution 1:02:26 Retinoids, vitamin C, and advanced therapies for skin repair 1:08:45 Dr. Mamina’s skincare routine and ingredient safety 1:14:55 Chemical vs. mineral sunscreens and rapid-fire takeaways 1:17:28 Where to find Dr. Mamina and learn about DermClick 1:18:15 Dr. Hyman’s new book, health lessons, and daily self-care 1:19:43 Supporting the show, following Dr. Hyman, and podcast disclaimer 1:20:21 Finding practitioners, Ultra Wellness Center, and closing thanks

Nutrition advice often reduces food to calories, nutrients, and a list of rules to follow. But the more we learn about how the body responds to different foods, the clearer it becomes that this way of thinking tells only part of the story. Today, I’m joined by cardiologist and public health expert Dr. Dariush Mozaffarian, director of the Food is Medicine Institute at Tufts University and author of the new book Food Is Medicine. We explore what we still get wrong about food and what changes when we begin treating it more like medicine. Here’s what we discuss: Why eating less and exercising more may not lead to lasting weight loss, and what to focus on instead How to choose foods that work with your appetite, metabolism, and microbiome rather than relying on calorie counting What GLP-1 medications can teach all of us about hunger, cravings, and why weight isn’t simply about willpower How much protein you actually need and why the source matters What the science says about seed oils and which processed foods are worth avoiding Over the years, I’ve learned to focus less on counting calories or chasing a single nutrient and more on the quality of the food itself. When you eat real, whole foods, the signals that regulate hunger and energy can begin to work with you instead of against you. Eating well should be less about following rules and more about understanding what helps your body function at its best. View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journalhttps://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Healthhttps://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive This episode is brought to you by Cozy Earth, Made In, Fatty15, Pique, Paleovalley, and BIOptimizers. Upgrade your sleep setup with cozyearth.com and enjoy 20% off with code HYMAN. Explore kitchen essentials at madeincookware.com and save 10% off your first order with code HYMAN-HIVE. Head to fatty15.com/HYMAN today and use code HYMAN for 15% off your 90-day subscription Starter Kit. Elevate your daily wellness ritual at piquelife.com/hyman and enjoy 20% off plus free gifts. Shop nutrient-rich foods and supplements at paleovalley.com/hyman and save 15% off your first order. Shop Magnesium Breakthrough at bioptimizers.com/hyman and save 15% with code HYMAN. 0:00 The paradox of rising obesity, calorie intake, and the importance of food quality over willpower 2:00 Introduction to Food is Medicine and Dr. Hyman’s mission 4:25 How medical training ignored nutrition and early challenges to low-fat dogma 7:48 Cardiac diets, processed carbs, and failures in nutrition science translation 10:54 The food system’s role in chronic disease and its national impact 12:15 Food as a health, economic, environmental, and equity issue 15:05 How science, policy, and business shaped the modern food system 18:14 Fixing the food system using the same forces that created it 19:04 The birth of modern nutrition science and discovery of vitamins 20:15 Deficiency diseases, vitamin fortification, and enriched grains 23:16 The green revolution, famine fears, and calorie-focused agriculture 27:04 Low-fat advice, tobacco-era marketing, and the rise of ultra-processed food 31:29 Misapplied nutrient thinking: fat vilification and chronic disease 33:30 Why calories in, calories out fails for obesity and weight control 36:53 Thermogenesis, brown fat, and food quality’s impact on metabolism 39:25 The microbiome’s role in calorie harvesting and weight regulation 41:03 Real food vs. calorie counting for long-term weight control 43:09 GLP-1, the microbiome, and how the food system hijacks appetite 48:27 Feeding your inner garden: microbiome foods, prebiotics, and protective foods 50:47 Food as medicine: adding good foods vs. deprivation 52:36 Food as a fast, personalized therapy for chronic disease 54:11 What ultra-processed food is and why it’s harmful 59:59 Why junk food isn’t food, and the protein craze explained 1:00:44 How much protein you need and why the source matters 1:03:55 Best protein sources and the dangers of processed meats 1:05:58 Seed oils, trans fats, omega-6s, and omega-3 deficiency 1:13:57 Why food system change is needed, not just individual willpower 1:15:20 Policy levers for fixing agriculture, labeling, regulation, and nutrition science 1:17:29 How health care can drive food as medicine 1:21:58 How investing in healthy food can reshape markets and outcomes 1:22:44 Food industry lobbying, misinformation, and policy challenges 1:25:07 Business innovation to shift toward healthier food products 1:26:03 Ultra-processed foods as “coal” and replacing them with clean food 1:26:25 What listeners can do in their communities and with officials

You can know exactly how you want to eat and still find yourself reaching for something else when you’re stressed or exhausted. I’ve been there. Our relationship with food is influenced by far more than nutrition knowledge, and blaming ourselves for struggling doesn’t help us understand what’s actually happening. Today, I’m joined by clinical psychologist Dr. Rachel Goldman, author of When Life Happens, to talk about the biology and psychology behind cravings, emotional eating, and food noise. We also explore how to care about nutrition without letting food rules take over your life. Here’s what we get into: Why you may reach for food when what you really need is rest, comfort, or a break How to pause before an automatic food choice and figure out what’s driving it How rigid food rules can turn one choice into a cycle of guilt and overeating How GLP-1s can quiet food noise, and what they can’t change about your relationship with food How to build other ways to cope when food has become your go-to response to stress I know what it’s like to want the cookie even when I know it isn’t what I really need. Knowing better doesn’t make us immune to being human. My hope is that this conversation helps you meet those moments with more curiosity and less blame, so your relationship with food can become a source of nourishment rather than stress. View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journalhttps://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Healthhttps://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive This episode is brought to you by Seed, Paleovalley, Timeline, Rho, Sunlighten, and Seatopia. Make your microbiome part of your daily routine with seed.com/hyman and save 25% with code 25HYMAN. Shop nutrient-rich foods and supplements at paleovalley.com/hyman and save 15% off your first order. Support healthy aging and get up to 20% off when you subscribe on top of the new starting price of $79 at timeline.com/drhyman. Explore science-backed products at rhonutrition.com and use code HYMAN for 20% off the entire site. Discover why so many people are using sunlighten.com. Use code HYMAN to save up to $2,100 today and free shipping. Find a cleaner source of seafood. Check out seatopia.fish and use code HYMAN for free shipping on your first order. 0:00 Introduction: Food industry, brain/microbiome hijack, and Dr. Rachel Goldman 1:17 Challenges in our relationship with food and emotional eating 4:25 Societal messages, body image, and the problem with body comments 6:17 Cognitive behavioral therapy for eating behaviors 9:54 The power of pausing and mindful eating 16:20 Emotional vs. physical hunger and mindful eating 22:17 Stress, sleep, and their impact on hunger and food choices 25:21 The myth of willpower, cravings, and brain studies 31:39 Food addiction, biology, and focusing on controllable actions 35:15 Coping tools and stress management 38:32 Diaphragmatic breathing and managing stress 40:36 Orthorexia, restrictive eating, and seeking professional help 45:19 The restriction-binge cycle and building a healthy relationship with food 49:29 Creating and sustaining a healthy relationship with food 56:08 Critiques of psychiatric practice and the GLP-1 phenomenon 1:00:30 Psychological aspects of weight loss and GLP-1 medications 1:02:58 Fixing biology vs. addressing psychology in eating 1:03:44 Long-term strategies and resources for eating disorders 1:07:00 The psychology of eating, self-talk, and episode conclusion

Chronic illness rarely fits neatly into a single diagnosis. Symptoms can span multiple systems, leaving people profoundly unwell even when standard testing appears normal. I understand this experience from the inside out because I’ve lived it myself. Today, I sit down with Dr. Neil Nathan, a leading expert in complex chronic illness and author of Toxic, now in its second edition. We explore why these conditions are so often misunderstood and how identifying what is driving them can create a path toward recovery. We discuss: Why mold toxicity, Lyme disease, and long COVID can be so difficult to diagnose How to identify the root cause instead of chasing downstream symptoms What the Cell Danger Response is and why the body can remain stuck in survival mode Why some people suddenly become sensitive to foods, chemicals, medications, light, and sound Why the right treatment can make symptoms worse when introduced at the wrong time I’ve been sick enough to know how quickly chronic illness can narrow your world—and how discouraging it is when no one can explain why. But I’m also living proof that the body can recover. The answer is not always more treatment. Often, it begins with finding the root cause, respecting what the body can tolerate, and addressing each layer in the right order. View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by BIOptimizers, Cozy Earth, Perfect Amino, Seatopia, Made In, and BON CHARGE. Shop Magnesium Breakthrough at bioptimizers.com/hyman and save 15% with code HYMAN. Upgrade your sleep setup with cozyearth.com and enjoy 20% off  with code HYMAN. Help fill protein gaps at bodyhealth.com and use code HYMAN20 for 20% off. Find a cleaner source of seafood. Check out seatopia.fish and use code HYMAN for free shipping on your first order. Shop for kitchen essentials at madeincookware.com and save 10% off your first order with code HYMAN-HIVE. Explore red light products at boncharge.com/hyman and enjoy 15% off with code HYMAN. (0:00) Introduction and Dr. Hyman's health journey (3:11) Challenges and limitations of conventional medicine (5:03) Environmental toxins and chronic illness (7:21) Identifying root causes and treatment order (16:14) Dr. Hyman’s mold struggle, toxicity vs. sensitivity (21:01) Dr. Nathan’s books and diagnosing chronic illnesses (28:53) Treatment strategies: primary cause, gut health, and mold (34:22) Addressing limbic, vagal, and mast cell issues first (39:52) Complexities of treating tick-borne infections (44:46) Emotional and psychological aspects of recovery (45:04) Encouragement and hope for chronic illness sufferers (46:36) Closing remarks and podcast info

This week, I’m the one answering the questions in a deeply personal conversation about my health journey. I speak openly about some of the hardest parts of that journey, the treatments I’ve tried, the beliefs I’ve reconsidered, and what a lifetime devoted to health has taught me about what matters most. Here’s some of what I share: How becoming the patient changed the way I practice medicine How nearly dying changed what longevity means to me and what I believe a healthy life is actually for Which wellness and longevity therapies I personally use, and how I decide what’s worth trying Why the pursuit of optimal health can sometimes become unhealthy What I’m still trying to understand about myself at this stage of my life I’ve spent much of my life trying to understand how we can live longer and feel better. But nearly losing my own life reminded me that health isn’t the destination. It’s what allows us to be present for the people we love, remain curious, and experience our lives more fully. I hope this conversation encourages you to ask yourself what you want your health to make possible. Continue exploring: Watch my conversation with Dr. Tyna Moore here. Learn more about my Brainshaping Academy here. View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journalhttps://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Healthhttps://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive This episode is brought to you by Paleovalley, BIOptimizers, Timeline, Rho, Sunlighten, and Pique. Shop nutrient-rich foods and supplements at paleovalley.com/hyman and save 15% off your first order. Shop Magnesium Breakthrough at bioptimizers.com/hyman and save 15% with code HYMAN. Support healthy aging and get up to 20% off when you subscribe on top of the new starting price of $79 at timeline.com/drhyman. Explore science-backed products at rhonutrition.com and use code HYMAN for 20% off the entire site. Discover why so many people are using sunlighten.com. Use the code HYMAN to save up to $2,100 today and free shipping. Elevate your daily wellness ritual at piquelife.com/hyman and enjoy 20% off plus free gifts. (0:00) Dr. Hyman's health decline, initial back surgery, and introduction to Q&A session (1:51) Dr. Hyman's early career, first herniated disc, and subsequent back surgeries (10:55) Mercury poisoning and its impact on health (17:06) Discovery of functional medicine and Jeffrey Bland's influence (20:27) Impact of personal health journey on Dr. Hyman's career and recovery from major surgery (24:04) Reflections on mortality, peace during surgery, and the role of spirituality and psychedelics (26:21) Changes in perspective on longevity, health, and specific recovery strategies (30:06) Navigating physiological depression and relationship with body as we age (33:48) Rapid-fire health tools: cold plunges, sauna, and more (43:32) IV therapy, red light therapy, and stem cell therapy for recovery (47:26) Exosomes and critique of wellness industry trends (50:31) Risks of over-testing, over-supplementation, and underrated treatments in functional medicine (58:13) Dr. Hyman's personal life, hobbies, and balancing passion with well-being (1:04:51) The Ultramind Solution, mental health, and root cause analysis in MS (1:07:06) Focus on strength training, functional health, and shifts in health understanding (1:09:23) Surprising changes in beliefs and impact of becoming a grandfather (1:11:42) Career reflections, ongoing curiosity, and closing remarks (1:14:38) Disclaimer and gratitude to sponsors

We hear a lot about improving gut health through food, probiotics, and supplements. But after more than a decade of major advances in microbiome research, the picture has become both more promising and more complex. In this episode, I’m joined by gastroenterologist and neuroscientist Dr. Emeran Mayer, co-author of the new book The Mayer Model, to explore how our understanding of the gut-brain connection has evolved—and what we may still be getting wrong. We also look at what this growing field could mean for chronic disease and healthy aging. Here’s what you’ll learn: How your gut microbiome communicates with your brain, immune system, hormones, and metabolism Why diet alone may not be enough to improve gut health—and how sleep, stress, exercise, relationships, and purpose also shape your microbiome How modern diets and lifestyles have created a mismatch between our microbes and human biology Why probiotics and microbiome testing may not provide the personalized answers many people expect How fiber, polyphenols, fermented foods, and greater plant diversity help support a healthier, more resilient microbiome The food we eat matters, but so do the ways we move, sleep, manage stress, and connect with others. Supporting gut health isn’t about finding one magic solution. It’s about creating a healthier, more resilient system over time. Beginning September 1, Dr. Mayer’s team is offering my audience a collection of bonuses to accompany The Mayer Model. To learn more about the book and access the bonuses, click here. View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Seed, Seatopia, Made In, PerfectAmino, BON CHARGE, and BIOptimizers. Make your microbiome part of your daily routine with seed.com/hyman and save 25% with code 25HYMAN. Find a cleaner source of seafood. Check out seatopia.fish and use code HYMAN for free shipping on your first order. Explore kitchen essentials at madeincookware.com and save 10% off your first order with code HYMAN-HIVE. Explore red light products at boncharge.com/hyman and enjoy 15% off with code HYMAN. Help fill protein gaps at bodyhealth.com and use code HYMAN20 for 20% off. Shop Magnesium Breakthrough at bioptimizers.com/hyman and save 15% with code HYMAN.

ADHD can go unnoticed for decades, especially in women who learn to compensate through perfectionism, overpreparing, and working under pressure. It often isn’t until the demands of work, motherhood, or another major life transition become too much that the underlying struggle comes into view. In this episode, I sit down with ADHD counselor Jenna Free, author of The Simple Guide to ADHD Regulation, to explore what she calls the frantic-crash cycle. She explains how chronic fight-or-flight may intensify ADHD symptoms and why nervous system regulation can make other tools and strategies easier to use. You’ll learn: Why women and high achievers can compensate for ADHD for decades before their usual coping strategies stop working How perfectionism, procrastination, and working under pressure can keep the frantic-crash cycle going The physical signs of nervous system dysregulation, including shallow breathing, muscle tension, and rushing even when there’s no real urgency Why calming your body is only the first step in creating lasting change How you can move away from all-or-nothing behavior and build a more sustainable way of getting things done A diagnosis can help you understand how your brain works, but it doesn’t have to define what’s possible. By learning to recognize and regulate survival mode, you can create the conditions for your brain to work at its best. View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive This episode is brought to you by Bioptimizers, Fatty15, Timeline, Rho, Seed, and Sulighten. Shop Magnesium Breakthrough at bioptimizers.com/hyman and save 15% with code HYMAN. Head to fatty15.com/HYMAN today and use code HYMAN for 15% off your 90-day subscription Starter Kit. Support healthy aging and get up to 20% off when you subscribe on top of the new starting price of $79 at timeline.com/drhyman. Explore science-backed products at rhonutrition.com and use code HYMAN for 20% off the entire site. Make your microbiome part of your daily routine with seed.com/hyman and save 25% with code 25HYMAN. Discover why so many people are using sunlighten.com, use code HYMAN to save up to $2,100 today and free shipping. 0:00 Understanding the impact of fight or flight and overview of ADHD discussion 2:01 Functional medicine approach to neurodevelopmental issues 4:38 Rising ADHD diagnoses in adults and coping strategies 9:25 Life transitions and the unmasking of ADHD 13:22 Revisiting fight or flight’s role in ADHD and urgency as a motivator 19:24 Differentiating ADHD from chronic dysregulation 24:03 Nervous system regulation for everyone and ADHD regulation stages 25:46 Physical, thought, and behavioral regulation techniques 41:53 Motherhood, stress, and overlooked signs of ADHD in women 44:28 Gaps in traditional ADHD training and new perspectives for clinicians 48:09 Recognizing dysregulation in daily life and common signs 51:29 Supporting partners and mothers with ADHD 53:16 Positive aspects and living well with ADHD 54:51 Jenna Free’s book, resources, and podcast conclusion

By the time memory begins to slip, the changes affecting the brain may have been developing for decades. But the trajectory isn’t fixed, and many of the factors driving it are within our control. In this episode, I sit down with my longtime friend and mentor Dr. David Perlmutter, six-time New York Times bestselling author whose new book, Brain Defenders, rethinks what it really takes to protect the brain as we age. You’ll learn: Why protecting your brain should begin long before memory problems appear How your daily choices influence whether the brain’s immune cells shift into a protective or damaging state Which numbers to know now, including fasting insulin, blood sugar, and waist-to-hip ratio How food, exercise, sleep, gut health, and environmental toxins shape your brain’s future What emerging research reveals about slowing—and even improving—cognitive decline I’ve always appreciated how David’s work replaces fear with something far more useful: a clearer understanding of how the choices we make today can help protect our memory, independence, and quality of life for years to come. View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Paleovalley, Pique, Perfect Amino, BON CHARGE, Cozy Earth, and Fatty15. Shop nutrient-rich foods and supplements at paleovalley.com/hyman and save 15% off your first order. Elevate your daily wellness ritual at piquelife.com/hyman and enjoy 20% off plus free gifts. Help fill protein gaps at bodyhealth.com and use code HYMAN20 for 20% off. Explore red light products at boncharge.com/hyman and enjoy 15% off with code HYMAN. Upgrade your sleep setup with cozyearth.com and enjoy 20% off  with code HYMAN. Head to fatty15.com/HYMAN today and use code HYMAN for 15% off your 90-day subscription Starter Kit.

GLP-1 medications have changed how we treat obesity and metabolic disease. But as their use has exploded, so have questions about side effects, muscle loss, long-term use, and whether patients are receiving the support they need to use them safely. In this episode, I reconnect with metabolic health and regenerative medicine expert Dr. Tyna Moore to revisit our conversation from two years ago and examine what we’ve learned since. We discuss: How to tell when your GLP-1 dose may be too high What you can do to protect your muscle and bone during weight loss Which metabolic and nutritional markers should you check before and during treatment Why weight can sometimes return after stopping a GLP-1 What emerging research suggests about GLP-1s beyond weight loss GLP-1s can be life-changing, but a lower number on the scale isn’t the same as better health. Ultimately, how these medications are used—from dosing and monitoring to nutrition and strength training—matters just as much as whether they’re used at all. Additional resources: Join Dr. Tyna Moore’s community Listen to Dr. Tyna Moore’s previous appearance on The Dr. Hyman Show View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journalhttps://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Healthhttps://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive This episode is brought to you by Seatopia, Perfect Amino, Cozy Earth, Timeline, Sunlighten, and Made In. Find a cleaner source of seafood. Check out seatopia.fish and use code HYMAN for free shipping on your first order. Get daily protein support at bodyhealth.com and use code HYMAN20 for 20% off. Head over to cozyearth.com to save 20% and upgrade all of your daily essentials today. Support healthy aging and get 20% at timeline.com/drhyman with code HYMAN. Discover why so many people are using sunlighten.com and use code HYMAN to save up to $2,100 today with free shipping. Upgrade your cookware at madeincookware.com and save 10% off your first order with code HYMAN-HIVE. (0:00) Introduction, Dr. Hyman's evolving views, and episode goals (0:43) Sponsor: Rose Nutrition Liposomal NAD (1:42) Sponsor: Seatopia clean seafood box (2:44) Disclaimers and Lyme disease preview (4:04) Guest Dr. Tina Moore reintroduced (4:30) GLP-1s: Effects after years and microdosing strategies (7:14) Risks of high-dose GLP-1s and misconceptions about muscle/bone loss (13:09) Functional deficiencies and microdosing approaches (17:05) Sponsor: Made In stainless clad cookware (18:02) Sponsor: Timeline with Mitopure (18:58) Broader and additional benefits of metabolic health and GLP-1s (21:48) GLP-1s for immune and brain health; genetic differences (27:59) Introduction to peptides and GLP-1 drugs (32:36) Gray market concerns and weight regain after stopping GLP-1s (37:14) Long-term safety, cost, and personalizing GLP-1 treatment (40:57) Emotional blunting and recent concerns about GLP-1s (46:30) Functional medicine approach: addressing root causes (46:46) Sponsor: Sunlighten Sauna (47:20) Sponsor: Magnesium Breakthrough from Bio Optimizers (48:17) Dr. Hyman’s evolving perspective on GLP-1s (49:19) Hormonal effects of GLP-1s for men and women (55:02) Baseline lab markers and tests before GLP-1s (57:10) New and next-gen GLP-1 therapies (59:43) Telemedicine, gray market issues, and importance of reputable practitioners (1:05:57) Rapid fire: Alcohol, common mistakes, misconceptions, and eligibility for GLP-1s (1:08:16) Key lab tests and surprising non-weight benefits

Heart disease is still the leading cause of death worldwide. Yet many people assume it only happens to those who are older, out of shape, or obviously unhealthy. In this episode, I sit down with cardiovascular surgeon Dr. Jeremy London, whose own heart attack challenged many of the assumptions we make about heart health. We discuss why prevention isn't always as straightforward as it seems—and how understanding your personal risk can help you take a more proactive approach to your health. We cover: Why some healthy people still develop heart disease The difference between standard cholesterol tests and a more complete assessment How to better understand your personal cardiovascular risk The lifestyle changes that can help lower your long-term cardiovascular risk Interested in more comprehensive lab testing? Learn more at Function and use code MARK2026 to save $50 on your membership. Heart disease is often preventable—but only if you know what to look for. Listen to my conversation with Dr. Jeremy London to learn how a better understanding of your personal risk can help you protect your long-term heart health. View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Paleovalley, Pique, Perfect Amino, Seed, BON CHARGE, and Cozy Earth. Shop nutrient-rich foods and supplements at paleovalley.com/hyman and save 15% off your first order. Elevate your daily wellness ritual at piquelife.com/hyman and enjoy 20% off plus free gifts. Help fill protein gaps at bodyhealth.com and use code HYMAN20 for 20% off. Support your gut health daily at seed.com/hyman and use code 25HYMAN for 25% off your first month. Explore red light products at boncharge.com/hyman  and enjoy 15% off with code HYMAN. Upgrade your sleep setup with cozyearth.com and enjoy 20% off  with code HYMAN.

Living with chronic illness can feel like collecting diagnoses without getting real answers. Symptoms are treated one at a time, but the underlying causes can easily be missed. What if asking a different question is the first step toward feeling better? In this episode, I’m joined by Dr. Richard Horowitz, an internationally recognized Lyme disease expert and author of the new book Ending Chronic Illness. After caring for thousands of patients over more than four decades, he explains why many seemingly unrelated conditions share common underlying drivers—and why thinking like a medical detective may help uncover them. We discuss: Why treating the diagnosis isn't always the same as treating the problem—and how to start looking deeper How hidden infections, environmental toxins, gut health, and other overlooked factors can quietly drive chronic illness What new research may reveal about the links between infection, inflammation, and brain health How to begin uncovering what's really driving persistent symptoms Our bodies are constantly communicating with us. The challenge isn't that they're silent—it's that we haven't always known how to listen. Sometimes finding better answers begins with asking different questions. Continue Exploring If you'd like to explore Dr. Horowitz's work further, here are two great places to start: Take his Symptom Assessment Quiz to better understand what may be contributing to your symptoms. Subscribe to his Medical Detective Substack ****for ongoing insights into chronic illness, Lyme disease, and root-cause medicine. Interested in getting tested? Many of the lab tests discussed in this episode are available through Function, making it easier to get a more comprehensive picture of your health. View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journalhttps://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Healthhttps://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive This episode is brought to you by Timeline, Cozy Earth, Seatopia, Perfect Amino, BON CHARGE, and Made In. Support healthy aging and get up to 20% off when you subscribe on top of the new starting price of $79 at timeline.com/drhyman. Upgrade your sleep setup with cozyearth.com and enjoy 20% off  with code HYMAN. Find a cleaner source of seafood. Check out seatopia.fish and use code HYMAN for free shipping on your first order. Help fill protein gaps at bodyhealth.com and use code HYMAN20 for 20% off. Explore red light products at boncharge.com/hyman  and enjoy 15% off with code HYMAN. Explore kitchen essentials at madeincookware.com and save 10% off your first order with code HYMAN-HIVE. (0:00) Infections and toxins as root causes of chronic illness; Dr. Horowitz's background and journey to functional medicine (5:37) Discovering and treating various infections, toxins, and Dr. Hyman's personal health story (9:16) Root causes of chronic disease, inflammation, and testing for infections and toxins (15:11) Sponsor: Seatopia and PerfectAmino (16:42) Importance of diet, addressing multiple health factors, and autoimmune misdiagnosis (19:26) Role of infections, toxins, microbiome, and leaky gut in autoimmune diseases and inflammation (21:06) Treating underlying causes and neuroinflammation in chronic diseases (24:37) Nutritional deficiencies, COVID-19, and the importance of sleep in chronic illness management (30:19) Plant medicines, supplements, and dapsone in treating neuroinflammation, Lyme, and Alzheimer's (41:30) Use of methylene blue in treatment protocols (44:56) Sponsor: Bon Charge (45:58) Sponsor: Made In (46:43) Evolution of treatment protocols and six principal causes of inflammation (50:18) Importance of adrenal function and hormone treatment in chronic illness (52:17) Differential diagnosis vs. root cause analysis and root cause testing (56:38) Horowitz's questionnaire and protocols for treating chronic infections (58:39) Addressing mold-related health issues and Dr. Hyman's personal experience (1:01:01) Mold testing, detoxification, and controversies in treatment (1:07:47) Insurance challenges and HHS innovation grant for chronic illness research (1:09:04) Importance of root cause medicine and Mark Hyman's upcoming book on longevity (1:11:56) Personalized medicine, reversing Alzheimer's biomarkers, and research funding priorities (1:15:02) Influence of Buddhist principles and personal experiences with chronic illness (1:16:01) Hope for patients, resources for learning, and closing remarks