
Fix Your Gut, Fix Your Hormones
From The Dr. Terri Show by Dr. Terri DeNeui, DNP
April 21, 2026 · 50 min
About this episode
This episode discusses the connection between gut health and hormone regulation, featuring insights from endocrinologist Dr. Cassie Smith.
Your Gut Is Controlling Your Hormones — And No One Told You You've done everything right. You're on hormone therapy. Your labs look fine. So why do you still feel terrible? The answer may have nothing to do with your hormone levels — and everything to do with what's happening in your gut. Most practitioners are treating your hormones and your gut as two completely separate systems. But they're not. Your estrogen is being processed, packaged, and either properly excreted or reabsorbed into your bloodstream based entirely on the state of your gut microbiome. If the bacteria in your gut are out of balance, that estrogen doesn't leave your body the way it should. It gets recirculated — in a damaged, more carcinogenic form. And that's just the beginning of what a dysbiotic gut does to your hormones. Dr. Terri sits back down with board-certified endocrinologist Dr. Cassie Smith, whose new book on the gut-hormone connection is already an Amazon bestseller, to pull back the curtain on the twenty to thirty percent of women who do everything right and still don't get better. The problem isn't the hormone. The problem is the gut that can't process it. This episode is for every woman who has…
People in this episode
Host: Dr. Terri DeNeui
Guest: Dr. Cassie Smith
Topics covered
- gut health
- hormones
- microbiome
- women's health
- endocrinology
Keywords
- gut microbiome
- hormone therapy
- estrogen
- brain fog
- mood swings
- dysbiosis
- women's health
Mentioned in this episode
Books & works: new book on the gut-hormone connection
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