About this episode

This episode discusses the challenges of misdiagnosis in multiple sclerosis and the potential impact of the revised 2024 McDonald Diagnostic criteria.

In this episode of the ECTRIMS Podcast, recorded in collaboration with the Multiple Sclerosis Journal "Controversies in MS" series, host Prof. Anneke van der Walt moderates a discussion between Prof. Andy Solomon and Prof. Enrique Gómez on one of the most debated developments in modern multiple sclerosis diagnosis. Together, they explore: • Why misdiagnosis remains a major challenge in MS care • The role of the central vein sign (CVS) and paramagnetic rim lesions (PRLs) in improving specificity • Whether expanding diagnostic sensitivity may increase false positives • The practical realities of implementing advanced MRI biomarkers globally • The importance of radiology training, implementation science, and AI-assisted imaging • How clinicians should approach MRI interpretation in real-world practice This conversation examines the balance between earlier diagnosis, diagnostic accuracy, and equitable implementation of emerging diagnostic tools across different healthcare settings. This episode is part of the MS Journal Controversies in MS series on The revised 2024 McDonald criteria can solve the misdiagnosis problem in MS . The accompanying Yes , No , and Commentary articles are…

People in this episode

Host: Prof. Anneke van der Walt

Guests: Prof. Andy Solomon, Prof. Enrique Gómez

Topics covered

• multiple sclerosis diagnosis
• misdiagnosis
• MRI biomarkers
• radiology training
• AI-assisted imaging
• diagnostic accuracy
• healthcare implementation

Keywords

• McDonald criteria
• multiple sclerosis
• misdiagnosis
• central vein sign
• paramagnetic rim lesions
• MRI interpretation
• diagnostic sensitivity
• radiology training
• AI imaging

Mentioned in this episode

Organizations: Multiple Sclerosis Journal, MS Journal

More episodes of The ECTRIMS Podcast

• How Geography, Healthcare Systems and Access Shape the Multiple Sclerosis Journey · July 16, 2026 · 27 min
• MS Research Briefs: MRI Biomarkers, Machine Learning and the Future of MS Diagnosis · July 2, 2026 · 24 min
• Vitamin D and Multiple Sclerosis: Separating Evidence from Expectation · June 18, 2026 · 31 min
• EBV and Multiple Sclerosis: Could Infection Hold the Key to MS? · May 15, 2026 · 29 min

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