Retatrutide Masterclass | Dosing, Side Effects, and the Framework Most People Get Wrong

Retatrutide Masterclass | Dosing, Side Effects, and the Framework Most People Get Wrong

May 19, 2026 · 51 min

About this episode

This episode is a masterclass on Retatrutide, covering its dosing, side effects, and common misconceptions.

All links here: https://hunterwilliamshealth.com/links 00:00 — Intro and why I'm doing these masterclasses 02:42 — What we're covering and the regulatory timeline 04:04 — The two users: weight loss vs longevity 05:30 — What Retatrutide actually does (the three receptors) 06:50 — Why the glucagon receptor makes Retatrutide different 07:54 — Weight loss trial data (1mg to 12mg) 10:50 — The longevity data: liver fat, ApoB, blood pressure 13:14 — Who the lean biohacker user is 13:50 — The titration playbook 15:32 — Once weekly vs split dosing 19:50 — Morning vs night injections 21:02 — How far to push the dose (why 8mg is the ceiling) 22:50 — How long to stay on and the regain problem 25:44 — Longevity maintenance protocol 26:34 — Lean user protocol 27:24 — Protein and training are non-negotiable 29:06 — Side effects and how to manage them 30:20 — The heart rate question and why I use taurine 32:00 — The weird skin sensitivity issue 33:48 — Pairing Retatrutide with testosterone 35:56 — Drug interactions (blood pressure, thyroid, insulin) 37:02 — Metrics that matter 38:42 — How to cycle off correctly 39:54 — The most common mistakes 40:42 — How to start, what to do if you plateau…

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