About this episode

In this masterclass, Hunter Williams breaks down the peptide MOTS-c, its effects on mitochondria, dosing guidelines, and potential side effects.

Links, cheatsheet, private group and more: ⁠https://hunterwilliamshealth.com/links In this masterclass I break down what MOTS-c actually is. It's a tiny peptide your mitochondria make when you exercise. It's the only major peptide coded inside the mitochondrial genome, not the cell nucleus. I get into how it flips the AMPK switch, your cell's main fuel gauge. I cover the dual action that lets it travel into the nucleus and turn on antioxidant genes. That part makes it pretty unique. Then I walk through the practical stuff. Who's a good candidate and who should skip it. My full dosing tiers, from a 250mcg screening dose up to 5mg. Cycling, reconstitution, and how I pair it with SS-31 and humanin. I also cover the side effect nobody warns you about. Around 10% of people react badly, and some of those reactions are serious. That's why I start low and work up slowly. A heads up on the evidence. Most of the exciting data is still animal models. Human data is thin, so I flag where I'm extrapolating. MOTS-c is more bioactive than its reputation suggests. Treat it with respect and it rewards you.

People in this episode

Host: Hunter Williams

Topics covered

• MOTS-c
• peptides
• mitochondria
• exercise
• dosing
• side effects
• antioxidant genes

Keywords

• MOTS-c
• peptide
• mitochondria
• exercise
• dosing
• side effects
• antioxidant
• AMPK
• bioactive

Mentioned in this episode

Products: MOTS-c, SS-31, humanin

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