The Tesamorelin Masterclass | The Complete User's Guide (2026)

About this episode

Hunter Williams provides a comprehensive guide to Tesamorelin, covering its effects on body composition, dosing strategies, and clinical data.

Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/links Tesamorelin is one of the few peptides I've seen actually move the needle on body composition. So I made a full masterclass on it. This is the user's guide as it stands in 2026. I cover what tesamorelin is, how it works, and the best practices I'd recommend for using it. We get into the growth hormone axis and why a GHRH is different from a GHRP. I break down the clinical data, the 15% visceral fat reduction, the liver fat numbers, and the cognition research almost nobody talks about. Then we get practical. Dosing, timing, fasted injections, and the cycling patterns I actually use. I share why I stay at one milligram instead of two and what the water retention tradeoff looks like at higher doses. I also cover stacking with testosterone and GLP-1s, reconstitution, injection technique, side effects, and the people who should skip this one entirely. I'm honest about the limits too. Some of this evidence is strong and some of it isn't. I tell you which is which. If you're thinking about tesamorelin or already using it, this is everything I'd want you to know.

People in this episode

Host: Hunter Williams

Topics covered

• peptides
• body composition
• growth hormone
• clinical data
• dosing
• injection technique

Keywords

• Tesamorelin
• body composition
• growth hormone axis
• visceral fat reduction
• dosing
• injection technique
• side effects

Mentioned in this episode

Organizations: hunterwilliamshealth.com

Products: Tesamorelin

More episodes of The Hunter Williams Podcast

• Saturday Morning Coffee Talk 6/6/26 · June 6, 2026 · 2h 15m
• The Complete TB-500 Masterclass: Dosing, Stacking, and More · June 5, 2026 · 30 min
• Reader Mailbag 4 — Peptide Overdoses, GLP-1 Anhedonia & Hormone Truths · June 2, 2026 · 1h 11m
• The May 2026 Q&A | Retatrutide, Testosterone, Autoimmune, and Beyond · May 29, 2026 · 59 min
• The SS-31 Masterclass | Dosing, Stacking, Cycling, and Why It's A Top 3 Peptide · May 26, 2026 · 42 min
• Peptides and Cancer | 20+ Studies the Critics Won't Show You · May 22, 2026 · 30 min