Mitochondria, Muscle, & Aging: What Longevity Drugs Miss | Dr. Mark Tarnopolsky | The Metabolic Link Ep. 88

Mitochondria, Muscle, & Aging: What Longevity Drugs Miss | Dr. Mark Tarnopolsky | The Metabolic Link Ep. 88

From The Metabolic Link by Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field

February 24, 2026 · 1h 32m · Episode 88

About this episode

Dr. Mark Tarnopolsky shares his journey of peak performance and the challenges he faced, exploring the intersection of mitochondria, muscle, and aging.

Dr. Mark Tarnopolsky's VO2 max was once 87.6 ml/kg/min — an elite-level mark few humans have reached. He's competed at three world championships in three different sports. He's also had three cardiac ablation surgeries, bled from his bowels after races, and watched his vision tunnel to a speck crossing a finish line. His story is a master class in where the line falls between peak performance and self-destruction. Now 63, Tarnopolsky is a neurologist, neuromuscular disease specialist, and sup...

People in this episode

Hosts: Dr. Dominic D'Agostino, Dr. Angela Poff, Victoria Field

Guest: Dr. Mark Tarnopolsky

Topics covered

  • mitochondria
  • muscle
  • aging
  • longevity drugs
  • peak performance
  • neurology

Keywords

  • VO2 max
  • neuromuscular disease
  • cardiac ablation
  • longevity
  • performance
  • aging

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