What Perimenopause Hormones Are Really Doing to Your Brain with Dr. Sarah E. Hill

What Perimenopause Hormones Are Really Doing to Your Brain with Dr. Sarah E. Hill

August 24, 2026 · 52 min

About this episode

This episode explores the impact of perimenopause hormones on brain function and emotional well-being with Dr. Sarah E. Hill.

What if the brain fog, anxiety, sleep problems, mood shifts—and even changes in how you see your partner—aren’t random? In this episode of The Midlife Realignment , I sit down with research psychologist and women’s hormone expert Dr. Sarah E. Hill to unpack what perimenopause hormones are really doing to the brain . Sarah explains how estrogen and progesterone influence far more than our reproductive systems. They affect how quickly our brains process information, how emotionally sensitive we feel, our sexual desire, our response to stress, and even the qualities we find attractive in a partner. And when those hormones begin fluctuating and declining during perimenopause? You can feel like somebody changed the operating system without telling you. We talk about why perimenopause brain fog can appear even when your periods are still regular, how declining progesterone may contribute to anxiety and sleep problems, and why declining estrogen can affect memory and cognitive sharpness. We also get into hormone therapy—including the important distinction between progesterone and synthetic progestins—and Sarah shares her own decision to begin estrogen and progesterone in her 40s. Plus…

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