
The episode discusses OpenAI's chief scientist's manifesto on AI alignment and features guests analyzing the implications of recent developments in AI.
This Week In Startups is made possible by: PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at paypal.launch.co Today’s show: OpenAI's chief scientist wrote a lengthy manifesto arguing that no lab has solved alignment, mere days after GPT-6 Astra shipped. Jason and Lon are joined by Tudor Achim of Harmonic, Alex Elias of Qloo, and Ahmed Ahres of Reactor to figure out if that's genuine alarm being expressed or just another pre-IPO sales pitch and play for regulatory capture. Plus news broke while we were recording! OpenAI is claiming to have solved a second Millennium Prize problem, after a 25-year-plus weight. AND, who is paying influencers to tell you AI is wonderful/harmful? And why? Guests: Tudor Achim on X: https://x.com/tachim Harmonic: https://harmonic.fun/ Alex Elias on X: https://x.com/ape Qloo: https://www.qloo.com/ Ahmed Ahres on X: https://x.com/Boudatw Reactor: https://reactor.inc/ Relevant Links: Jakub Pachocki, "An Alien Mind" — https://openai.com/index/an-alien-mind/ GPT-6 Astra — https://fortune.com/2026/09/03/openai-debuts-gpt-6-astra-computer-use-greg-brockman-says-start-of-agi/ OpenAI: "On the…
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