
5,000+ Tech Workers Laid Off This Week. It's Just The Beginning. | E2286
From This Week in Startups by Jason Calacanis
May 9, 2026 · 1h 12m
About this episode
The episode discusses recent tech layoffs and the implications for AI in regulated industries.
This Week In Startups is made possible by: IM8 Health - https://IM8health.com/TWIST Every - Every.io Sentry - https://Sentry.io/TWIST Banks don’t want to hand over their data to AI labs. So David Moscatelli built a $250,000 box that runs AI on-prem. He already has 1,600 pre-orders. On today’s episode of TWiST, Jason and Alex sit down with the Go Abacus founder and Yanez's Jose Caldera to unpack how regulated industries are getting AI without the cloud, why Bittensor subnet 54 is incentivizing miners to attack identity systems, and why Cloudflare just laid off 20% of its workforce in the same week it raised guidance. The show closes with Jason explaining what it means to build an AI-first startup, and how workers can derisk their future employment! Guest Links: Go Abacus Go1 direct link David Moscatelli on LinkedIn Yanez Bittensor Subnet 54 on TAOstats Jose Caldera on LinkedIn LAUNCH Links: Founder University Founder University Japan application portal News Links: Cloudflare lays off 20% of its staff Coinbase cuts 14% of its staff Block post on how it is rebuilding its company Block’s earnings, including its raised guidance Anthropic’s massive upcoming funding round WHOOP’s new…
People in this episode
Host: Jason Calacanis
Guests: Alex, David Moscatelli, Jose Caldera
Topics covered
- tech layoffs
- AI infrastructure
- regulated industries
- employment risks
- cloud computing
- startup advice
Keywords
- tech layoffs
- AI
- Cloudflare
- employment
- startup
- Go Abacus
- David Moscatelli
- Jose Caldera
Sponsors
IM8 Health, Every, Sentry
Mentioned in this episode
Organizations: Go Abacus, Yanez, Cloudflare, Coinbase, Block, Anthropic, WHOOP, Stripe Atlas
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