IBD augmentation of CHIP and Platelet mTOR's impact on Cerebral Malaria
About this episode
This episode discusses how inflammation drives blood and immune-related diseases, featuring insights on IBD and cerebral malaria.
In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Reuben Kapur and Robert Campbell on their latest articles published in Blood . This episode highlights two groundbreaking studies exploring how inflammation drives serious blood and immune-related diseases. In the first interview, Dr. Kapur discusses how inflammatory bowel disease (IBD) can both promote and worsen clonal hematopoiesis of indeterminate potential (CHIP) , with large-scale human data and mouse models identifying REF1 as a key mediator and potential therapeutic target. The second segment features Dr. Campbell, who explains how heme released during malaria infection activates platelet mTOR signaling, intensifying cerebral malaria and suggesting new avenues for platelet-targeted treatments . Together, the conversations reveal how inflammatory pathways and immune signaling contribute to disease progression while opening the door to novel precision therapies.
People in this episode
Host: Dr. Laurie Sehn
Guests: Dr. Reuben Kapur, Dr. Robert Campbell
Mentioned in this episode
Organizations: Blood, American Society of Hematology
More episodes of Blood Podcast
- Review Series on Clonal Tracking in Hematopoiesis
- New Approaches: Marstacimab Therapy and HLH Biomarkers
- Review Series on Hemophagocytic Lymphohistiocytosis (HLH)
Explore listener stats, chart rankings, contacts and more on the Blood Podcast podcast page.