New Approaches: Marstacimab Therapy and HLH Biomarkers
From Blood Podcast by American Society of Hematology
May 28, 2026 · 18 min · Season 11
About this episode
This episode features an interview discussing marstacimab therapy for hemophilia and new biomarkers for HLH.
In this week's episode, Blood editor Dr. James Griffin interviews Drs. Johnny Mahlangu and Joseph Rocco on their articles published in volume 147 issue 9 of Blood . Dr. Mahlangu discusses study details and next steps from " Efficacy and safety of marstacimab prophylaxis in hemophilia A/B with inhibitors: results from the phase 3 BASIS trial " which shows that bleeding was reduced by 93% with subcutaneous marstacimab. Dr. Rocco shares the development behind " CXCL9 as a novel prognostic marker to identify high-risk adults with hemophagocytic lymphohistiocytosis ", and the insights gained from measuring a new surrogate marker of IFN-γ activity predicting severity and mortality.
People in this episode
Host: Dr. James Griffin
Guests: Dr. Johnny Mahlangu, Dr. Joseph Rocco
Topics covered
- marstacimab therapy
- hemophilia
- HLH biomarkers
- prognostic markers
- clinical trials
Keywords
- marstacimab
- hemophilia A
- hemophilia B
- HLH
- CXCL9
- prognostic marker
- clinical trial
- BASIS trial
- IFN-γ activity
Mentioned in this episode
Organizations: Blood
Books & works: Efficacy and safety of marstacimab prophylaxis in hemophilia A/B with inhibitors: results from the phase 3 BASIS trial, CXCL9 as a novel prognostic marker to identify high-risk adults with hemophagocytic lymphohistiocytosis
More episodes of Blood Podcast
- Future Directions in Relapsed and Refractory Large B-cell Lymphoma · June 11, 2026 · 25 min
- Review Series on Clonal Tracking in Hematopoiesis · June 4, 2026 · 30 min
- Review Series on Hemophagocytic Lymphohistiocytosis (HLH) · May 21, 2026 · 16 min
- IBD augmentation of CHIP and Platelet mTOR's impact on Cerebral Malaria · May 14, 2026 · 21 min
- Long-term efficacy and safety of betibeglogene autotemcel for β-thalassemia · May 7, 2026 · 13 min
- Effects of ZNF467 on HSPC fitness and Promotion of Follicular Lymphoma via DC-SIGN · April 30, 2026 · 22 min
Explore listener stats, chart rankings, contacts and more on the Blood Podcast podcast page.