Spatial-Omics and Machine Learning in Muscle Stem Cell Repair (Will Wang)
About this episode
The episode features a discussion with Will Wang about his research on muscle stem cell repair and the role of spatial-omics and machine learning in regenerative biology.
In this episode of the Epigenetics Podcast, we talked with Will Wang from Sanford Burnham Prebys about his work on muscle stem cell repair, regeneration, and aging, exploring spatial-omics and machine learning. We begin our conversation by exploring the traditional concepts of spatial biology and how they have evolved to play a critical role in disease research. Dr. Wang recounts his journey from a young student in a family of academics to becoming a leading figure in regenerative biology, highlighting how his early interests in life sciences, natural problem-solving abilities, and inspirations from mentorship set the stage for his current research trajectory. Throughout the discussion, we uncover key insights on how muscle stem cells transition from a quiescent state to a proliferative state in response to injury and how this dynamic process is governed by the epigenetic landscape and various signalling pathways. Dr. Wang emphasises the impact of external factors—be it microenvironment conditions or metabolic cues—on the fate and function of these stem cells, reflecting on the methodologies used to investigate these processes throughout his career. He shares fascinating findings…
People in this episode
Guest: Will Wang
Topics covered
- muscle stem cell repair
- spatial-omics
- machine learning
- regenerative biology
- epigenetics
- aging
Keywords
- muscle stem cells
- regeneration
- epigenetic landscape
- transcription factors
- metabolism
- histone acetylation
Mentioned in this episode
Organizations: Sanford Burnham Prebys
More episodes of Epigenetics Podcast
- Epigenetic Signatures During Aging and Cancer (Alena van Bömmel)
- Cryo-EM and the Dynamics of TFIID and PRC2 (Eva Nogales)
- RNA modifications and Gene Expression (Michaela Frye)
- Polycomb and Three-Dimensional Genome Organisation (Oliver Bell)
- From Placeholder Nucleosomes to Zygotic Genome Activation (Patrick Murphy)
- Decoding Cell Fate Through 3D Genome Organization and Chromatin Dynamics (Srinjan Basu)
Explore listener stats, chart rankings, contacts and more on the Epigenetics Podcast podcast page.