Ep. 584 "Slowing the Engine” – How GLP-1s Alter Your Gut Motility & Microbiome | Menopause, Perimenopause & Gut Health

Ep. 584 "Slowing the Engine” – How GLP-1s Alter Your Gut Motility & Microbiome | Menopause, Perimenopause & Gut Health

From Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+ by Everyday Wellness™

April 23, 2026 · 21 min

About this episode

This episode discusses the impact of GLP-1 medications on gut motility and microbiome in relation to midlife weight changes and hormonal shifts.

Welcome to today’s Midlife Minute. In this episode, I answer listeners’ questions about GLP-1 medications and midlife weight changes. I explore how hormonal shifts, insulin sensitivity, muscle mass, and the gut microbiome influence the effectiveness of these drugs, and explain why they should be regarded as part of a broader metabolic and lifestyle framework. IN THIS EPISODE, YOU WILL LEARN: Why GLP-1 medications don’t necessarily fix the root cause of midlife weight gain How declining estrogen can disrupt your appetite and satiety hormones The value of checking your fasting insulin to understand your insulin sensitivity level How inadequate protein can cause cravings for processed carbohydrates and fats Why preserving muscle mass is critical to prevent sarcopenic obesity How GLP-1 medications affect digestion and gut motility The clinical factors that are considered when prescribing GLP-1 medications Some simple daily habits to support your metabolic and microbiome health when using GLP-1 medications Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a…

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