Approaching MDS: Advances in Diagnostics, Therapeutics and Monitoring

Approaching MDS: Advances in Diagnostics, Therapeutics and Monitoring

From HemeTalks: Conversations in Hematology Education by American Society of Hematology

April 16, 2026 · 25 min · Season 5 · Episode 21

About this episode

This episode discusses advances in the diagnosis and management of myelodysplastic neoplasms with expert insights from Drs. DeZern and Mack.

Join us for an insightful discussion on myelodysplastic neoplasms (or MDS) with Drs. DeZern and Mack as we review the current standards in diagnosis of MDS using cutting edge molecular techniques. This marrow failure syndrome requires thoughtful and accurate diagnosis to ensure appropriate risk assessment for clinical decision making. We will then review relevant therapeutic choices and how to monitor on and off therapy through the case of a 68 yo male with a 6-year history of disease. We will explore key diagnostic considerations, the distinct testing required for prognostication and the therapies available in lower and high-risk disease. This episode offers practical, evidence-based insights to enhance the recognition and management of MDS. Learning Objectives: Understand accurate diagnostic testing needed in MDS including core and aspirate, iron stain, IHC, and molecular diagnostics (MK and NGS) Review limited therapeutic options currently available in MDS Discuss management strategies at each stage of this disease from lower risk to higher risk with suitable monitoring plans Clinical Pearls: Comprehensive diagnosis and reassessment during disease course guide best practices…

People in this episode

Guests: Dr. DeZern, Dr. Mack

Topics covered

  • myelodysplastic neoplasms
  • diagnostics
  • therapeutics
  • monitoring
  • risk assessment
  • case study

Keywords

  • MDS
  • diagnosis
  • therapeutics
  • monitoring
  • molecular techniques
  • risk assessment
  • case study
  • cytopenia

Mentioned in this episode

Organizations: American Society of Hematology

Books & works: myelodysplastic neoplasms, MDS

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