New Horizons in Smoldering Multiple Myeloma
From HemeTalks: Conversations in Hematology Education by American Society of Hematology
March 19, 2026 · 26 min · Season 5 · Episode 20
About this episode
Professors Brea Lipe and Sagar Lonial discuss the evolving treatment strategies for smoldering multiple myeloma and the importance of differentiating it from related conditions.
Join Professor Brea Lipe and Professor Sagar Lonial as they discuss the changing treatment landscape of smoldering multiple myeloma (SMM). With a recently approved treatment for high-risk SMM, knowing how to differentiate and manage SMM compared with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) has never been more crucial. Professors Lipe and Lonial review the case of a 58-year-old man in good health with no anemia or other health concerns, whose annual checkup reveals an isolated finding of elevated total protein. As they follow this patient’s journey, they discuss best practice in diagnosis, risk stratification, and management of SMM. Finally, they consider the factors affecting decision-making in the context of data from early intervention trials that aimed to either delay progression to active MM or, potentially, to cure SMM. Learning Objectives: Explain the distinction between MGUS, SMM and MM Describe the key tests required for a basic workup of a case of suspected clonal plasma cell disorder Explain how patients with SMM may be risk-stratified Evaluate the factors that influence the decision to treat or monitor a case of high-risk SMM…
People in this episode
Guests: Brea Lipe, Sagar Lonial
Topics covered
- smoldering multiple myeloma
- treatment landscape
- risk stratification
- clinical trials
- plasma cell disorders
Keywords
- smoldering multiple myeloma
- MGUS
- multiple myeloma
- risk stratification
- clinical trials
- treatment management
Mentioned in this episode
Organizations: American Society of Hematology
Places: United States
More episodes of HemeTalks: Conversations in Hematology Education
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- Multiple Myeloma Care: Timing, Teamwork, Treatment · May 21, 2026 · 23 min
- Atención del Mieloma Múltiple: Oportunidad, Trabajo en Equipo y Tratamiento · May 21, 2026 · 22 min
- TTP Today: Diagnosis, Management & Evolving Therapies · May 7, 2026 · 20 min
- Approaching MDS: Advances in Diagnostics, Therapeutics and Monitoring · April 16, 2026 · 25 min
- Interpreting Abnormal SPEP – Is It Just MGUS? · February 19, 2026 · 27 min
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