42. Why Your Hormones Haven't Improved Despite Treatment - The Role of Inflammation, Histamine & Methylation

42. Why Your Hormones Haven't Improved Despite Treatment - The Role of Inflammation, Histamine & Methylation

April 6, 2026 · 14 min · Episode 42

About this episode

Joanne explores the reasons why hormone symptoms persist despite treatment, focusing on inflammation, histamine, and methylation.

In this in-depth episode of The Histamine Well Podcast, Joanne explores why hormone symptoms often persist despite treatment, and what may be driving this beneath the surface. Drawing on clinical observation and biochemistry, Joanne explains how chronic inflammation, histamine dysregulation, and methylation imbalances interact to disrupt hormonal signaling, ovulation, and recovery. If you’ve tried supplements, improved your diet, and still experience symptoms like PMS, PMDD, anxiety, insomnia...

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