#428: Poop, Peptides & The Power of Microbiome | The Secret Longevity Organ With Dr. Grace Liu

#428: Poop, Peptides & The Power of Microbiome | The Secret Longevity Organ With Dr. Grace Liu

April 10, 2026 · 1h 25m

About this episode

Dr. Grace Liu discusses the critical role of gut health in longevity and its impact on various aspects of health.

Today, I'm joined by Dr. Grace Liu, often known as the “Gut Goddess,” a trailblazer in the world of microbiome science and founder of The Gut Institute. In this conversation, we take a bold dive into an often-overlooked pillar of longevity: your poop. That's right—Dr. Liu unpacks the fascinating and sometimes surprising science showing how gut health shapes everything from your immune system and brain to your lifespan itself. Episode Timestamps: Introduction to host ... 00:00:00 Dr. Grace Liu on the gut as a hallmark of aging ... 00:04:06 Peptides, FMT, and evidence for gut-driven regeneration ... 00:05:04 FMT safety, immune education, and the environmental “microdosing” effect ... 00:07:07 Links between gut aging, the immune system, and mental health ... 00:08:13 Diet, ancestry, and resistant starch for butyrate production ... 00:15:01 Ancestral diet, microbiome differences, and pitfalls of shortcuts ... 00:18:53 Fiber, polyphenols, and the key longevity bacteria ... 00:24:09 Gut markers, loss of diversity, and ABC species signature ... 00:25:15 Risks of overhyped probiotics, strep, and broad interventions ... 00:36:29 Peptides, bioregulators, and repairing the gut ... 01:12:01…

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