LONGEVITY with Nathalie Niddam

Today, I’m joined by Dr. Andrew Salzman, a pioneer in NAD research whose work has spanned everything from pediatric sepsis to cutting-edge longevity science. Dr. Salzman dives deep into why NAD isn’t just another supplement buzzword, but a central molecule powering our energy, resilience, and even fertility. Wonderfeel is gifting a 7-day Youngr™ supply with every Youngr™ order. Click here and use code NAT at checkout to claim your complimentary gift. Offer ends two weeks from today’s episode. Episode Timestamps: Introduction ... 00:00:00 Scientific rigor in supplement development ... 00:06:49 Evolution of medicine and the role of populist health ... 00:09:37 Changing views on aging and longevity ... 00:14:13 NAD’s role in energy, repair, and aging ... 00:17:22 When NAD starts to decline and why it matters ... 00:21:06 Early signs of NAD deficiency ... 00:22:22 NAD’s connection to fertility and reproductive health ... 00:25:03 Gut health, inflammation, and NAD depletion ... 00:34:16 Lifestyle and diet drivers of NAD loss ... 00:39:35 How to assess NAD needs ... 00:42:11 Boosting NAD: supplement strategies and limits ... 00:44:09 NMN versus NR and dosing ... 00:46:05 Wonderfeel’s approach: address depletion and boost levels ... 00:51:53 Commonly reported results and user feedback ... 00:54:52 Creatine’s critical role in cellular energy and aging ... 00:57:55 Future directions: criticism, biomarkers, and personalization ... 01:10:10 Podcast wrap-up, offers, and disclaimer ... 01:15:09 Our Amazing Sponsors: Quantum Upgrade – A 24/7 quantum energy streaming service designed to support energy, focus, sleep, recovery, and a more balanced nervous system, backed by placebo-controlled research showing measurable improvements in stress-related brain activity and heart rate variability. Try it free for 15 days with no credit card required at QuantumUpgrade.io and use code NAT15. Micro-BOOST (Humic Mineral Complex) by BEAM Minerals - A concentrated liquid humic formula that binds and removes toxins like heavy metals, mold, and pollutants—working fast with just a daily shot. Head to http://www.beamminerals.com/NAT20, use code NAT20, and get 20% off your first order. Daily Gut Detox by Just Thrive Health – A gentle, science-backed detox powered by clinically proven immunoglobulins that bind and remove toxins while supporting your gut, immune system, and digestion—without harsh flushing or discomfort. Visit JustThriveHealth.com/NAT20 and use code NAT20 for 20% off your order, risk-free. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Today, I’m joined by the incredibly insightful Donna Jackson Nakazawa, a science journalist and bestselling author whose work bridges the worlds of neuroscience, storytelling, and personal transformation. Donna has a unique gift for translating complex brain science into real-life strategies—and she’s not afraid to weave in her own powerful journey, from childhood trauma and autoimmune challenges to her fierce quest for hope and healing. Episode Timestamps: Podcast introduction and episode overview ... 00:00:00 Chronic stress, childhood adversity, and lifelong health ... 00:07:04 Microglia as the link between stress and brain changes ... 00:10:47 Protector vs destroyer: microglia’s dual role in the brain ... 00:11:21 Neuroplasticity and hope for healing at any age ... 00:15:19 Modern stressors and impacts on kids’ brain health ... 00:17:25 Safety, rumination, and reshaping the brain’s wiring ... 00:18:22 Donna’s personal journey with trauma and autoimmune illness ... 00:38:00 How to break rumination: the MIST framework ... 00:47:40 The science and power of language on health ... 01:01:00 Daily practice tips to disrupt negative thought cycles ... 01:07:26 Rethinking longevity: focus on healthspan and connection ... 01:10:03 How to preorder the book and connect online ... 01:11:38 Podcast outro and disclaimer ... 01:13:02 Our Amazing Sponsors: Ultimate GI Repair by LVLUP Health — a research-backed blend of peptides, zinc carnosine, and gut-support compounds designed to strengthen your gut lining, improve digestion, and support resilience from the inside out; head to lvluphealth.com and use code NAT for 20% off MassZymes by BiOptimizers – A full-spectrum digestive enzyme formula with 4x more protease to help break down protein into usable amino acids so your body actually benefits from what you eat—try it risk-free with a 365-day money-back guarantee and save 15% at bioptimizers.com/bionat with code BIONAT. Vita Zero-Age Exosomes by Vitali Skincare — a regenerative “stacking” formula with exosomes, GHK-Cu, niacinamide, and glutathione designed to support your skin at a cellular level rather than just the surface; go to www.vitaliskincare.com/?ref=Nat20 and use code NAT20 for 20% off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Today, I’m joined by Kyal Van Der Leest, an innovative naturopath, nutritionist, and founder of LVLUP Health, whose formulas are changing the way we think about effective supplementation. Kyal’s journey is deeply personal: from caring for his mother through a long battle with cancer, to overcoming his own intense health struggles with mold illness. These experiences led him to push past superficial fixes and dig deep into what really works for healing and optimizing the body. Visit www.lvluphealth.com and use code NAT for 20% off Previous Episodes: Episode #116: Does the Perfect Gut Supplement Exist? Episode #148: Kyal Van Der Leest: Liver Health, Gut Health, and Detoxification #326: From Brain Fog to Focus: Techniques and Supplements to Enhance Cognitive Function With Kyal Van Der Leest Episode Timestamps: Welcome & Podcast intro ... 00:00:00 Pitfalls of cheap supplements & importance of quality ... 00:05:33 Mistakes: symptom chasing, green allopathy, and root causes ... 00:07:38 Blending naturopathy, biochemistry, and biohacking ... 00:10:26 Choosing peptides, herbs, or vitamins for target outcomes ... 00:16:43 Synergy, proprietary blends, and dosing transparency ... 00:18:06 Understanding supplement forms, dosages, and stack simplification ... 00:24:29 Root cause thinking: brain fog, labs, and interconnected symptoms ... 00:34:16 Dopamine, focus, and the risks of overstimulation ... 00:39:59 Peptides in brain health—a step beyond herbs or nutrients ... 00:43:00 Short-term nootropics vs. long-term investments in brain health ... 00:46:17 Longevity levers: muscle, blood sugar, and blood flow ... 00:51:04 Blood sugar regulation—berberine, dihydroberine, and alternatives ... 00:53:32 Liver’s core role in hormones and energy ... 00:55:59 Heart and lung health—peptides, circulation, and overlooked systems ... 01:00:10 Peptides vs. herbs—when to choose and when to avoid ... 01:04:21 Future of peptides, supplement quality, and industry direction ... 01:07:45 Hierarchy: Foundations before biohacks ... 01:08:57 Simple, high-impact upgrade picks & final advice ... 01:11:17 Industry trends, influencer issues, and episode wrap ... 01:17:01 Where to find Kyal and promo code details ... 01:19:19 Our Amazing Sponsors: Sunlighten: Up to $2,100 off + FREE shipping Sunlighten Sauna - Looking to support your recovery and calm your nervous system? Sunlighten offers full spectrum infrared saunas—compact enough for real homes, powerful enough to support detoxification, mitochondrial energy, and a smarter longevity routine. Visit get.sunlighten.com/natpodcast and use code natlongevity to get $2,100 off + FREE shipping. Apollo Neuro — A wearable nervous system support device that uses personalized SmartVibes technology to help you feel calmer, more focused, and better able to shift into rest mode without adding another complicated wellness routine. Head to apolloneuro.com/nat Offer to receive 20% off. Vampire Exosome by Young Goose - A next-generation serum packed with three trillion PRP-derived exosomes and RejuvNAD to support collagen production and skin renewal at the cellular level—helping results build over time instead of fading fast. Shop at younggoose.com and use code NAT10. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Today, I’m flying solo to tackle a topic that’s essential for anyone invested in their health: how to truly vet your supplements. With new products hitting the shelves daily and wellness marketing louder than ever, it’s easy to get swept up in the latest hype—but more isn’t always better, and sometimes it can actually make things worse. Episode Timestamps: Welcome and podcast introduction ... 00:00:00 Baseline biomarker testing before supplementing ... 00:04:21 Risks with supplementing without testing ... 00:06:06 Third-party certification for supplement quality ... 00:08:18 Supplement contamination issues ... 00:08:55 Seals to look for and their limits ... 00:09:54 Efficacy and scientific evidence hierarchy ... 00:10:53 Limitations of animal/cell data vs. human trials ... 00:13:05 Red flags in supplement marketing ... 00:15:12 "Natural" isn’t always safe—drug interactions and toxicity ... 00:15:58 Fat-soluble vitamin risks and safe disclosure ... 00:18:12 Form and bioavailability importance ... 00:21:07 Optimal vs. poor supplement forms ... 00:21:25 Timing, combinations, and activated forms ... 00:23:13 Dose: fairy dusting, blends, and megadosing dangers ... 00:25:15 Checklist summary for supplement decisions ... 00:31:25 Conclusion and disclaimer ... 00:33:03 Our Amazing Sponsors: Vita Zero-Age Exosomes by Vitali Skincare — a regenerative “stacking” formula with exosomes, GHK-Cu, niacinamide, and glutathione designed to support your skin at a cellular level rather than just the surface; go to www.vitaliskincare.com/?ref=Nat20 and use code NAT20 for 20% off. Apollo Neuro — A wearable nervous system support device that uses personalized SmartVibes technology to help you feel calmer, more focused, and better able to shift into rest mode without adding another complicated wellness routine. Head to apolloneuro.com/NATN Offer to receive 20% off. Ultimate GI Repair by LVLUP Health — a research-backed blend of peptides, zinc carnosine, and gut-support compounds designed to strengthen your gut lining, improve digestion, and support resilience from the inside out; head to lvluphealth.com and use code NAT for 20% off Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Today, I’m joined by Andrea Donsky, a powerhouse nutritionist, menopause advocate, and author of the groundbreaking new book Nourishing Menopause. In our conversation, Andrea opens up about her deeply personal journey—how experiencing her first hot flash as a nutrition expert pushed her into years of curiosity, research, and ultimately, a mission to reimagine menopause as both a challenge and an opportunity. Episode Timestamps: Welcome, show intro, and purpose ... 00:00:00 Lack of menopause awareness and connecting symptoms ... 00:07:02 Mainstream vs. holistic menopause approaches ... 00:09:09 Surveying thousands of women and symptom discovery ... 00:11:16 Validating unusual menopause symptoms ... 00:13:41 Impact on relationships and the workplace ... 00:21:04 Early onset, variability, and importance of hormonal testing ... 00:25:32 Key takeaways: you’re not alone, support exists ... 00:28:16 Ovarian aging and overall health ... 00:29:47 Shifts in women’s health research ... 00:32:11 Designing impactful, diverse menopause surveys ... 00:33:41 Andrea’s “Nourishing Menopause” book philosophy ... 00:35:12 Nourishment, longevity, and healthspan ... 00:37:23 Risks of muscling through menopause ... 00:39:52 Insulin resistance: causes, signs, and management ... 00:45:57 Meal timing, fasting, and metabolic flexibility ... 00:51:06 Personalized health testing and nutrition ... 00:56:0 Soy/phytoestrogen controversy ... 00:58:08 BALANCE blueprint and nutrition pillars ... 01:01:18 Managing stress, nervous system, and reframing menopause ... 01:05:31 Andrea’s non-negotiables and top practical tips ... 01:09:11 Our Amazing Sponsors: LongeFera by Regenerive - Most cheap Ashwagandha is bulked up with stems and leaves to inflate the “actives.” Those parts can bring compounds you don’t actually want in your body. LongeFera — fixes that with a root-only extract containing four newly identified bioactives, the ASHX4 Complex. Visit regenerive.co and use code NAT25 for 25% off. Micro-BOOST (Humic Mineral Complex) by BEAM Minerals - A concentrated liquid humic formula that binds and removes toxins like heavy metals, mold, and pollutants—working fast with just a daily shot. Head to http://www.beamminerals.com/NAT20, use code NAT20, and get 20% off your first order. CP1 Pure Collagen Peptides by Puori — a clean, unflavored collagen that supports connective tissue, joints, and skin elasticity with a unique amino acid profile your body actually uses, plus Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Today, I’m thrilled to welcome Dr. Nasha Winters back to the show for part two of our powerful conversation. As a trailblazer in integrative oncology and a passionate advocate for the “metabolic terrain” approach to health, Dr. Winters brings both deep expertise and a truly holistic perspective to the complex world of cancer and longevity. In this episode, she doesn’t just share concepts—she takes us into the heart of what it means to test, assess, and address our own health in real life, especially when we’re facing major diagnoses and difficult decisions. Episode Timestamps: Welcome & Introduction to Longevity Podcast ... 00:00:00 Metabolic Terrain Concept & Mitochondrial Health ... 00:05:00 The Test, Assess, Address Framework ... 00:08:08 Readiness, Honest Audit, and Lifestyle Evaluation ... 00:08:43 The Ten Terrain Drops in Cancer & Health ... 00:14:09 Emotional Foundations for Healing ... 00:15:01 Essential Lab Markers and the “Trifecta” ... 00:16:52 Affordable, Early Detection Labs—CBC, CRP, LDH, ESR ... 00:17:32 Shift Work, Circadian Health, and Mitigating Strategies ... 00:29:11 Handling Overwhelm: Prioritizing Fundamentals ... 00:37:45 Prevention Myths: Sun, Meat, and Food Access ... 00:42:26 Home-Cooked Food & Community’s Healing Power ... 00:51:16 Behaviors That Seem Healthy But Aren’t (e.g., Excess Cardio) ... 00:54:55 Age-Specific Advice and Building Longevity ... 00:56:25 Cancer, Metabolic Flexibility, and Biomarker “Under Five” Rule ... 01:02:32 Integrative Oncology’s Strengths & Misconceptions ... 01:08:48 Risks of Extreme Alternative or Mainstream Approaches ... 01:12:58 Post-2020: Changing Health Trends & Immune Patterns ... 01:17:03 Hope for the Future & Patient Empowerment ... 01:24:02 Our Amazing Sponsors: STEMREGEN by Stemregen - A daily formula designed to support your body’s natural repair systems by helping release your own stem cells into circulation, supporting recovery, resilience, and whole-body renewal at the source. Visit stemregen.co/NAT15 and use code NAT15. https://stemregen.co/NAT15 Vampire Exosome by Young Goose - A next-generation serum packed with three trillion PRP-derived exosomes and RejuvNAD to support collagen production and skin renewal at the cellular level—helping results build over time instead of fading fast. Shop HERE and use code NAT10. Bioregulators by Nature’s Marvels - targeted peptides designed to support cellular signaling and renewal across key systems like circadian rhythm, immune function, and vascular health as part of a foundational longevity stack; head to profound-health.com and use code NAT15 for 15% off your first order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Today, I’m joined by the one and only Dr. Sandra Kaufmann—a true pioneer in the field of personalized longevity medicine and the creative force behind the Kaufman Protocol. In this episode, Sandra shares how a personal curiosity about why we age at the cellular level ultimately drew her away from a successful anesthesia career and into the world of building longevity strategies for real people. She opens up about the moment longevity became more than just an intellectual pursuit, and the surprising ways her work has grown into a global movement. Previous episodes: Episode #203: Everything You Need to Know About The Theory of Aging with Dr. Sandra Kaufmann Episode #55: Dr. Sandy Kaufmann Longevity Expert – Sneak Peak at 3 New AntiAging Compounds That Have Earned a Spot in Her New Book Episode Timestamps: Welcome, podcast intro and longevity focus ... 00:00:00 The importance of truly individual longevity interventions ... 00:09:00 Problems with cholesterol oversimplification and statins ... 00:11:09 Fuel utilization changes with age and hormone shifts ... 00:14:38 Introduction to the Kaufman Protocol’s framework ... 00:17:39 Pitfalls of copying others’ supplement stacks and extreme trends ... 00:21:21 Iron overload and personalized assessment strategies ... 00:24:46 Lab testing, history, and personalized follow-up ... 00:38:04 Deep dive: mast cells, inflammation, and aging ... 00:39:15 Mast cell stabilization options and estrogen’s influence ... 00:44:49 Defining “superagers” and their core habits ... 00:58:34 Big misconceptions in anti-aging medicine (rapamycin, etc.) ... 01:05:52 Peptides, exosomes, and where advanced tools fit in a pyramid ... 01:07:31 Emerging testing, refined supplements, and the future ... 01:11:59 Three key questions to assess your personal aging priorities ... 01:18:24 Our Amazing Sponsors: Tro Zzz by Troscriptions – A fast-acting sleep troche that dissolves in your cheek and combines melatonin with compounds like honokiol, adenosine, cordycepin, CBD, CBN, and 5-HTP to support deep, restorative sleep when travel, stress, or late workouts throw things off. Head to troscriptions.com and use code NAT10 for 10% off your first order. Ultimate GI Repair by LVLUP Health — a research-backed blend of peptides, zinc carnosine, and gut-support compounds designed to strengthen your gut lining, improve digestion, and support resilience from the inside out; head to lvluphealth.com and use code NAT for 20% off Mitopure Gummies by Timeline - These clinically researched gummies support mitophagy to help renew your mitochondria and boost cellular energy, giving you a stronger biological foundation for resilience—visit timeline.com/NAT20 to get 20% off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

Today, I'm joined by the legendary Dr. Jeffrey Bland, widely known as the "father of functional medicine" and a true pioneer in the science of longevity and immune resilience. In this conversation, Dr. Jeffrey Bland opens up about his decades-long journey questioning the conventional medicine model, the personal moments that shaped his mission, and how his passion for asking the right questions ultimately led him to reshape the future of healthcare. Visit Bigboldhealth.com/NAT and get 15% off automatically at checkout. Episode Timestamps: Focus on immune system aging ... 00:00:00 Questioning conventional medicine and the roots of chronic disease ... 00:05:00 Functional medicine and influences like Linus Pauling ... 00:12:39 Dangers of oversimplification and the limits of biohacking ... 00:17:21 Evolving thinking on supplements and the power of cycling and personalization ... 00:19:37 Why immune resilience trumps immune boosting for longevity ... 00:25:21 Diet's impact on immune cell turnover and long-term health ... 00:28:57 Autoimmunity, CHIP cells, inflammaging, and biological individuality ... 00:32:04 Microbiome, mitochondria, and immune-driven fatigue ... 01:00:07 The 4R gut and immune program as a starting point ... 01:06:26 Movement, lymphatics, and rejuvenation ... 01:08:35 Food as information, epigenetics, and practical recommendations ... 01:11:25 90-day immune system renewal and rapid-fire takeaways ... 01:31:40 Our Amazing Sponsors: Quantum Upgrade - Supports nervous system balance without wearables or apps—just effortless, 24/7 quantum energy streaming. With 21+ studies showing measurable improvements in stress and cellular function, it's easy to try for yourself. Visit quantumupgrade.io/NAT and use code NAT15 to start the free 15 day trial. Primeadine by Oxford Healthspan — A food-derived spermidine supplement that supports autophagy and cellular renewal without fasting, made from Japanese wheat germ with clean, rigorously tested ingredients (including a gluten-free option); visit oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout. PW1 by Puori — A clean, high-quality whey protein that's third-party tested for over 200 contaminants and smooth enough to feel like a treat while supporting muscle, metabolism, and bone strength. Go to puori.com/NAT and use code NAT for 32% off your first subscription or 20% off anything on the site. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode