Parkinson’s Disease and the Gut Microbiome Connection (feat. Martha Carlin)

Parkinson’s Disease and the Gut Microbiome Connection (feat. Martha Carlin)

April 15, 2026 · 48 min · Episode 350

About this episode

This episode explores the connection between gut health and Parkinson's disease, highlighting the implications of chronic constipation and gut bacteria.

What if your gut has been signaling a problem for your brain for years? That is exactly what the latest science on the gut microbiome and Parkinson's disease is revealing, and it begins with something as overlooked as constipation. If you have ever dismissed a sluggish digestive system as no big deal, this conversation may be the most important one you hear all year. Salad With a Side of Fries host Jenn Trepeck welcomes Martha Carlin, microbiome researcher, founder of The BioCollective and a woman who traded a corporate career for a microscope after her husband was diagnosed with Parkinson's at 44. What she has uncovered about gut bacteria, endotoxin load, the glycocalyx, and neurological decline is both startling and deeply actionable. This is not fear, it is fuel for better choices. What You Will Learn in This Episode: ✅ Why chronic constipation is far more than a digestive inconvenience and how waste sitting in the colon produces an endotoxin load now linked to Parkinson's, depression, autism, and diabetes. ✅ What the glycocalyx is, why it matters for everything from gut health to cardiovascular function, and how damage to this critical structure can spread throughout the…

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