About this episode

Dr. Mark Hyman discusses the root causes of autoimmune disease and how to begin healing through dietary and lifestyle changes.

Autoimmune disease is often treated as something random, lifelong, and out of your control. But what if it’s not your body malfunctioning—what if it’s your immune system responding exactly the way it’s designed to, to something it sees as a threat? When you understand what’s driving that response, everything changes. Here’s what I cover in today’s episode: • The 5 key drivers—food, toxins, gut health, infections, and stress—and how they disrupt the immune system • Why diet is one of the most powerful levers for turning inflammation on or off every single day • The connection between leaky gut, the microbiome, and immune dysfunction • A practical, functional medicine framework to start reducing symptoms and addressing the condition at the root Autoimmune disease isn’t random—it’s the result of cumulative inputs over time. When you begin to change those inputs, you can shift your biology, calm the immune system, and change the trajectory of your health. Visit ⁠functionhealth.com for 160+ lab tests at just $365 a year. Join the 10-Day Detox: https://drhyman.com/pages/10-day-detox Have a question you’d love answered on Office Hours? Submit it here The waitlist is open** Sign up for…

People in this episode

Host: Dr. Mark Hyman

Topics covered

• autoimmune disease
• immune system
• functional medicine
• diet
• inflammation
• gut health

Keywords

• autoimmune disease
• immune response
• diet
• inflammation
• gut health
• functional medicine
• leaky gut

Sponsors

Function Health

More episodes of The Dr. Hyman Show

• Is It Burnout Or Something Deeper? The High-Functioning Trap | Dr. Judith Joseph · June 10, 2026 · 1h 23m
• Why Your Cholesterol Is High—and How to Start Fixing It in 10 Days · June 8, 2026 · 24 min
• Antidepressants Explained: Benefits, Risks, and Alternatives for Depression | Dr. James Greenblatt · June 3, 2026 · 55 min
• The Perfect Morning Routine for a Longer, Sharper Life | Dr. Mark Hyman · June 1, 2026 · 18 min
• Millions of Women Stopped Taking Hormones Because of a Misread Study | Dr. Sharon Malone · May 27, 2026 · 1h 28m
• Is HRT Safe? 10 Questions Women Ask Most — Answered by a Functional MD · May 25, 2026 · 46 min

Explore listener stats, chart rankings, contacts and more on the The Dr. Hyman Show podcast page.