New Science of Weight Loss | A Masterclass

New Science of Weight Loss | A Masterclass

July 20, 2026 · 1h 55m · Season 1

About this episode

This episode explores the impact of GLP-1 medications on obesity treatment and metabolic health, featuring insights from multiple experts.

GLP-1 medications are transforming obesity treatment, but they're only one piece of the puzzle. In this masterclass, I bring together insights from Dr Terry Simpson, Dr Federica Amati, Dr Mauricio Gonzalez, Dr Christos Mantzoros, and Dr Stephan Guyenet to explain how these medications work, why "food noise" matters, and what it really takes to improve long-term metabolic health. What We Cover How GLP-1 medications regulate appetite and food noise Why obesity is more complex than willpower Semaglutide vs tirzepatide and newer medications Nutrition and resistance training while taking GLP-1s The role of fibre, protein, and Mediterranean-style eating Common misconceptions and side effects I hope this episode helps you better understand both the promise and the limitations of GLP-1 medications, while highlighting the importance of lifestyle alongside any medical treatment. Why Terry Simpson Started Taking a GLP-1 (00:00) What Is Food Noise, Really? (04:59) Why GLP-1 Drugs Work So Well (10:16) What Actually Causes Obesity (17:37) How GLP-1 Medications Work in the Body (21:22) The Strange Lizard Behind GLP-1 Drugs (25:56) 3 Types of Hunger You Didn't Know About (28:41) How to Naturally…

People in this episode

Host: Simon Hill

Guests: Dr Terry Simpson, Dr Federica Amati, Dr Mauricio Gonzalez, Dr Christos Mantzoros, Dr Stephan Guyenet

Topics covered

Keywords

Mentioned in this episode

Products: GLP-1 medications, Semaglutide, tirzepatide

Books & works: Mediterranean Diet

More episodes of The Proof with Simon Hill

Explore listener stats, chart rankings, contacts and more on the The Proof with Simon Hill podcast page.