Redefining Nutrition and Fitness with Mark Sisson

Redefining Nutrition and Fitness with Mark Sisson

From The Strong New York Podcast by Kenny Santucci

February 25, 2026 · 34 min · Episode 66

About this episode

Kenny Santucci interviews Mark Sisson about redefining nutrition and fitness, exploring his journey and insights on health and entrepreneurship.

In this episode of the Strong New York Podcast, Kenny takes the show on the road to the LA Fit Expo to sit down with health and wellness legend Mark Sisson. Mark—New York Times bestselling author, former elite endurance athlete, and founder of Primal Kitchen—shares how injuries from running led him to rethink fitness, nutrition, and footwear, ultimately creating the Primal Blueprint and Primal Kitchen. He breaks down his simple framework for long-term health (diet, walking, lifting, sprinting, and sleep), explains why metabolic flexibility matters, and challenges mainstream nutrition “science.” We also dive into entrepreneurship, lessons learned building iconic brands, and why Mark launched his minimalist footwear company Peluva to address foot health from the ground up. 00:00 Live from LA Fit Expo: Welcome & Why Fitness Events Matter 00:26 Meet Mark Sisson: Athlete, Entrepreneur & Early Biohacker 01:25 From Running Injuries to Evolutionary Biology (and Building a Career) 02:17 Primal Kitchen Origin Story: Fixing Diet Through Better Sauces 03:33 Facing Rejection: Defending Paleo, Epigenetics & Self-Experimentation 05:55 Science, Money & Nutrition Confusion: Why…

People in this episode

Host: Kenny Santucci

Guest: Mark Sisson

Topics covered

  • nutrition
  • fitness
  • entrepreneurship
  • health
  • metabolic flexibility

Keywords

  • nutrition
  • fitness
  • Mark Sisson
  • Primal Kitchen
  • metabolic flexibility
  • entrepreneurship
  • health

Mentioned in this episode

Organizations: Primal Kitchen, Peluva

Books & works: Primal Blueprint

Places: New York, LA Fit Expo

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