Drugs n Stuff 320 Why Steroid Cycles Stop Working (And How to Keep Growing) + PED QA

Drugs n Stuff 320 Why Steroid Cycles Stop Working (And How to Keep Growing) + PED QA

From Think BIG Bodybuilding by Think BIG Bodybuilding Media

July 20, 2026 · 1h 6m

About this episode

The episode discusses why steroid cycles become less effective over time and how to maintain growth in bodybuilding.

Why do steroids stop producing the same gains over time? In this episode of Drugs N Stuff, Scott McNally and Dave Crosland explain why simply running more drugs for longer eventually leads to diminishing returns—and how experienced bodybuilders structure long growth phases to keep making progress. Plus, we answer your questions on testosterone isocaproate, DHB, Dutasteride, Retatrutide, NAD+, P-21, sauna use, TRT injection frequency and much more. ⏱ TIMESTAMPS 0:00 Why Steroids Eventually Stop Working 1:00 Support Our Sponsors 3:45 How to Plan a 12-Month Growth Phase 13:40 Start Low, Build Slowly & Extend Your Cycle 20:30 Testosterone Isocaproate Half-Life Explained 24:10 Can You Re-Sensitize Yourself to Stimulants? 29:40 Scott's Experience with P-21 31:40 Selank: Scott's Honest Experience 32:50 Low-Dose Testosterone + DHB for a Specific Look 37:00 Sauna Benefits While Using PEDs 41:00 Can Retatrutide Reduce Addiction? 45:00 NAD+ Benefits & Can You Overdo Mitochondria? 48:45 Why Some Lifters Are Leaving Daily TRT Injections 49:45 Does Dutasteride Protect Against Dianabol Hair Loss? 51:50 Why Hydrochlorothiazide Is NOT Potassium Sparing 54:30 LSD as a Treatment for Depression…

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