658. Preventing Alzheimer's: Bridging Research and Practice with Dr. Dale Bredesen
About this episode
Greg LaBlanc interviews Dr. Dale Bredesen about his research on preventing Alzheimer's through a holistic approach to brain health.
Dale Bredesen is the senior director of the Precision Brain Health Program at Pacific Neuroscience Institute and also the founding CEO of the Buck Institute. He also has authored a number of books, including, most recently, The Ageless Brain: How to Sharpen and Protect Your Mind for a Lifetime and The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline. Greg and Dale discuss Dale’s “network insufficiency” view of Alzheimer’s that shifts focus from plaques alone to a balance of synaptic “supply and demand.” He argues the brain switches from connection to protection under chronic insults, which are microbes, inflammation, toxins, metabolic syndrome, sleep apnea, and poor energetics. Dale highlights tau phosphorylation as part of an antimicrobial response and APOE4 as a pro-inflammatory risk gene with evolutionary benefits. They also discuss diet, insulin resistance, exercise, sleep metrics, stress, and the case for prevention and combined approaches. *unSILOed Podcast is produced by University FM.*
People in this episode
Host: Greg LaBlanc
Guest: Dale Bredesen
Topics covered
- Alzheimer's prevention
- brain health
- cognitive decline
- network insufficiency
- diet and exercise
- insulin resistance
Keywords
- Alzheimer's
- brain health
- cognitive decline
- network insufficiency
- tau phosphorylation
- APOE4
- diet
- exercise
- insulin resistance
Mentioned in this episode
Organizations: Pacific Neuroscience Institute, Buck Institute
Books & works: The Ageless Brain: How to Sharpen and Protect Your Mind for a Lifetime, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline
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