Alexander Disease Research Update – Episode #26: Changes in gene expression and cognitive function in the rat model
About this episode
The episode discusses recent research on gene expression and cognitive function in a rat model of Alexander disease.
Send us Fan Mail Albee Messing, Tracy Hagemann, and Rob Berman discuss the following recent publication: [02:01] GFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with impaired synaptic plasticity and cognitive deficits in a rat model of Alexander disease eNeuro (in press) [full text] Send your questions and feedback to: amessing@wisc.edu Help support research on Alexander Disease at the University of Wisconsin-Madison's Wa...
People in this episode
Host: Albee Messing
Guests: Tracy Hagemann, Rob Berman
Topics covered
- gene expression
- cognitive function
- Alexander disease
- neurodegeneration
- rat model
- astrocyte dysfunction
Keywords
- Alexander disease
- gene expression
- cognitive function
- neurodegeneration
- rat model
- GFAP mutation
- astrocyte dysfunction
Mentioned in this episode
Organizations: University of Wisconsin-Madison
Books & works: GFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with impaired synaptic plasticity and cognitive deficits in a rat model of Alexander disease
More episodes of Alexander Disease Research Update
- Alexander Disease Research Update – Episode #31: 1) Development of an AxD Severity Score, and 2) Peer review – please come home
- Alexander Disease Research Update – Episode #30: 1) Speech-language impairments, and 2) GFAP concentrations in CSF and blood
- Alexander Disease Research Update - Episode #29: Genotype-phenotype correlations, or does variant predict course?
- Alexander Disease Research Update - Episode #28: GDF15, nausea, vomiting, and "failure to thrive"
- Alexander Disease Research Update – Episode #27: Genotype-phenotype association for 14 GFAP variants
- Alexander Disease Research Update – Episode #25: GFAP Variants in the UK Biobank - estimated prevalence of adult-onset AxD
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