Chapter Eighteen: Metabolic Alkalosis, part 2

About this episode

The episode discusses metabolic alkalosis, its physiological effects, and related studies.

References Part 2, March 1, 2023 The alkaline tide phenomenon in studies that measured both the alkaline tide and acid secretion, the bicarbonate accumulation increased in linear fashion with the acid secretion. Melanie thought this was first recognized in the 60’s but later found this manuscript from 1939 in JCI! ALKALINE TIDES - PMC Melanie mentioned this old study that explores the respiratory response of metabolic acidosis and finds it “incomplete” compared to expected. EVALUATION OF RESPIRATORY COMPENSATION IN METABOLIC ALKALOSIS and there’s another image in a review by Michael Emmett Figure 1. Metabolic Alkalosis: A Brief Pathophysiologic Review - PMC (here’s the image from JCI)  The effect of changes in blood pH on the plasma total ammonia level - Surgery This is an interesting case that Melanie mentioned with the help of Stew Lecker Trust the Patient: An Unusual Case of Metabolic Alkalosis - PMC Got Calcium? Welcome to the Calcium-Alkali Syndrome : Journal of the American Society of Nephrology a favorite review of the “calcium alkali” syndrome- previously called milk alkali syndrome but now milk is not commonly part of the syndrome (as with Dr. Sippie).  Lety…

Topics covered

• metabolic alkalosis
• alkaline tide
• respiratory compensation
• calcium-alkali syndrome
• urine pH
• drug contaminants

Keywords

• metabolic alkalosis
• alkaline tide
• respiratory compensation
• calcium-alkali syndrome
• urine pH
• drug contaminants

Mentioned in this episode

Organizations: JCI, Journal of the American Society of Nephrology, Trust the Patient, PMC, Surgery, Circadian variation in urine pH and uric acid nephrolithiasis risk

Books & works: Calcium-Alkali Syndrome, An Unusual Case of Metabolic Alkalosis, Metabolic Alkalosis: A Brief Pathophysiologic Review, Evaluation of Respiratory Compensation in Metabolic Alkalosis, Got Calcium?, Tranq Dope: Animal Sedative Mixed With Fentanyl Brings Fresh Horror to U.S. Drug Zones

More episodes of Channel Your Enthusiasm

• Chapter Twenty: Respiratory Acidosis · June 3, 2026 · 1h 45m
• Chapter Twenty One: Respiratory Alkalosis · March 24, 2026 · 1h 7m
• Chapter Nineteen: Metabolic Acidosis, part 3 · February 22, 2026 · 1h 58m
• Chapter Nineteen: Metabolic Acidosis, part 2 · October 11, 2025 · 1h 45m
• Chapter Nineteen: Metabolic Acidosis, The Show, part 1 · June 2, 2025 · 1h 45m
• Chapter Eighteen: Metabolic Alkalosis, part 1 · March 23, 2025 · 1h 6m