Chapter Seventeen: Introduction to Simple and Mixed Acid-Base Disorders

About this episode

This episode introduces simple and mixed acid-base disorders, discussing various studies and literature on the topic.

References I said I used MDCalc but I was mistaken I use MedCalX which is nice but getting dated.  We talked about this out of print book that we love: Cohen, J. J., Kassirer, J. P. (1982). Acid-base. United States: Little, Brown. Josh mentioned this article that looked at over 17,000 samples with simultaneous measured and calculated bicarbonate and found a very small difference. Comparison of Measured and Calculated Bicarbonate Values | Clinical Chemistry | Oxford Academic Base deficit or excess- Diagnostic Use of Base Excess in Acid–Base Disorders | NEJM (check out the accompanying letter to the editor from Melanie challenging this article! Along with colleagues Lecker and Zeidel Diagnostic Use of Base Excess in Acid-Base Disorders ) Melanie loves this paper which shows a nice correlation between arterial and venous pH but the rest of the comparisons are disappointing - Comparison of arterial and venous pH, bicarbonate, Pco2 and Po2 in initial emergency department assessment - PMC A nomogram for the interpretation of acid-base data is figure 17-1 in the book, this manuscript with the ! in the conclusion creates the acid-base map.  We debated about whether we like…

People in this episode

Host: Channel Your Enthusiasm

Topics covered

• acid-base disorders
• medical education
• clinical chemistry
• diagnostic methods
• dietary acid load

Keywords

• acid-base
• bicarbonate
• diagnostic use
• venous pH
• dietary acid load

Mentioned in this episode

Books & works: Cohen, J. J., Kassirer, J. P. (1982). Acid-base. United States: Little, Brown, Comparison of Measured and Calculated Bicarbonate Values | Clinical Chemistry | Oxford Academic, Diagnostic Use of Base Excess in Acid–Base Disorders | NEJM, Comparison of arterial and venous pH, bicarbonate, Pco2 and Po2 in initial emergency department assessment - PMC, Quantitative displacement of acid-base equilibrium in metabolic acidosis, Review of dietary acid load

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