About this episode

This episode discusses metabolic acidosis and its implications on kidney function and acid-base equilibrium.

References Chapter 19, Part 1  Metabolic acidosis  June 14, 2023 American Society of Nephrology | Medical Students - Kidney TREKS this is the program that Josh mentioned at Mount Desert Island!  Effects of pH on Potassium: New Explanations for Old Observations - PMC here’s the review melanie from Peter Aronson that clarifies the fact that there are no H+-K+ antiporters outside the kidney but rather coupled transport- We discussed whether we like “Winter’s formula” Quantitative Displacement of Acid-Base Equilibrium in Metabolic Acidosis | Annals of Internal Medicine   Dr. R. W. Winters was charged with larceny https://www.nytimes.com/1982/05/16/nyregion/ex-columbia-u-doctor-charged-with-larceny.html JCI - The Maladaptive Renal Response to Secondary Hypocapnia during Chronic HCl Acidosis in the Dog this was a classic experiment exploring the respiratory response to an infusion of HCl but the animals were maintained in a high pCO2 milieu (not generalizable to humans!) Here’s the thoughtful Pulmcrit post (by Josh Farkas)  that Josh mentioned regarding correction of anion gap for hypoalbuminemia: Mythbusting: Correcting the anion gap for albumin is not helpful…

People in this episode

Host: Channel Your Enthusiasm

Topics covered

• metabolic acidosis
• acid-base equilibrium
• renal response
• anion gap
• kidney function

Keywords

• metabolic acidosis
• kidney TREKS
• anion gap
• acid-base disturbance
• pH effects on potassium

Mentioned in this episode

Organizations: American Society of Nephrology, Mount Desert Island, Annals of Internal Medicine, NEJM, Pulmcrit

Books & works: Mythbusting: Correcting the anion gap for albumin is not helpful, Effects of pH on Potassium: New Explanations for Old Observations, Acid-base disturbance in patients with cirrhosis: relation to hemodynamic dysfunction, Diagnostic Importance of an Increased Serum Anion Gap

Places: New York

More episodes of Channel Your Enthusiasm

• Chapter Twenty One: Respiratory Alkalosis · March 24, 2026 · 1h 7m
• Chapter Nineteen: Metabolic Acidosis, part 3 · February 22, 2026 · 1h 58m
• Chapter Nineteen: Metabolic Acidosis, part 2 · October 11, 2025 · 1h 45m
• Chapter Eighteen: Metabolic Alkalosis, part 2 · July 22, 2025 · 1h 40m
• Chapter Eighteen: Metabolic Alkalosis, part 1 · March 23, 2025 · 1h 6m
• Chapter Seventeen: Introduction to Simple and Mixed Acid-Base Disorders · February 21, 2025 · 1h 32m

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